LTP is the most intensively studied cellular model of the memory and generally divided at
least two distinct phases as early and late. E-LTP requires activation of CaMKII that initiates …

Mammalian excitatory synapses express diverse types of synaptic plasticity. A major
challenge in neuroscience is to understand how a neuron utilizes different types of plasticity …

Arc (activity‐regulated cytoskeleton‐associated protein) is posited as a critical regulator of
long‐term synaptic plasticity at excitatory synapses, including long‐term potentiation, long …

Classical studies have shown that neuronal immediate-early genes (IEGs) play important
roles in synaptic processes critical for key brain functions. IEGs are transiently activated and …

Context-induced retrieval of drug withdrawal memory is one of the important reasons for
drug relapses. Previous studies have shown that different projection neurons in different …

The immediate early gene, Arc, is a pivotal regulator of synaptic plasticity, memory, and
cognitive flexibility. But what is Arc protein? How does it work? Inside the neuron, Arc is a …

Protease activity correlates with depressive or suicidal behaviors, with calpain activation
being especially implicated in depression-like behaviors. However, the role of calpain in …

The sense of taste is a key component of the sensory machinery, enabling the evaluation of
both the safety as well as forming associations regarding the nutritional value of ingestible …

Activity‐regulated cytoskeleton‐associated protein (Arc) is a protein interaction hub with
diverse roles in intracellular neuronal signaling, and important functions in neuronal …

The Arc gene is robustly transcribed in specific neural ensembles in response to experience-
driven activity. Upon induction, Arc mRNA is transported to dendrites, where it can be rapidly …