Biological functions of NLRP3 inflammasome: A therapeutic target in inflammatory bowel disease
Y Song, Y Zhao, Y Ma, Z Wang, L Rong, B Wang… - Cytokine & Growth …, 2021 - Elsevier
Cases of inflammatory bowel disease (IBD), a debilitating intestinal disorder with complex
pathological mechanisms, have been increasing in recent years, straining the capacity of …
pathological mechanisms, have been increasing in recent years, straining the capacity of …
NLRP3 inflammasome in digestive diseases: from mechanism to therapy
R Qiang, Y Li, X Dai, W Lv - Frontiers in Immunology, 2022 - frontiersin.org
Digestive system diseases remain a formidable challenge to human health. NOD-like
receptor family pyrin domain containing 3 (NLRP3) inflammasome is the most characteristic …
receptor family pyrin domain containing 3 (NLRP3) inflammasome is the most characteristic …
Kuijieyuan decoction improved intestinal barrier injury of ulcerative colitis by affecting TLR4-dependent PI3K/AKT/NF-κB oxidative and inflammatory signaling and gut …
B Liu, X Piao, W Niu, Q Zhang, C Ma, T Wu… - Frontiers in …, 2020 - frontiersin.org
Ethnopharmacological Relevance In Traditional Chinese medicine (TCM) theory, ulcerative
colitis (UC) is associated with damp-heat, blood stasis, and intestinal vascular ischemia …
colitis (UC) is associated with damp-heat, blood stasis, and intestinal vascular ischemia …
Febuxostat attenuates ulcerative colitis by the inhibition of NF-κB, proinflammatory cytokines, and oxidative stress in mice
K Amirshahrokhi - International Immunopharmacology, 2019 - Elsevier
Ulcerative colitis is a chronic inflammatory disorder characterized by oxidative stress and
upregulation of proinflammatory mediators in colonic tissue. Febuxostat, a xanthine oxidase …
upregulation of proinflammatory mediators in colonic tissue. Febuxostat, a xanthine oxidase …
[HTML][HTML] The effect of combining basil seeds and gum Arabic on the healing process of experimental acetic acid-induced ulcerative colitis in rats
MA Bejeshk, AH Aminizadeh, MA Rajizadeh… - Journal of Traditional …, 2022 - Elsevier
Background & aim Ulcerative colitis (UC) is a chronic recurrent inflammatory disease of the
large intestine and rectum that oxidative stress and severe inflammation are the main …
large intestine and rectum that oxidative stress and severe inflammation are the main …
Protective effects of iridoid glycosides on acute colitis via inhibition of the inflammatory response mediated by the STAT3/NF-кB pathway
J Yuan, W Cheng, G Zhang, Q Ma, X Li, B Zhang… - International …, 2020 - Elsevier
Morroniside and loganin are iridoid glycosides extracted from Cornus officinalis, a plant
species widely used in traditional Chinese medicine. However, the anti-inflammatory effects …
species widely used in traditional Chinese medicine. However, the anti-inflammatory effects …
Linagliptin ameliorates acetic acid-induced colitis via modulating AMPK/SIRT1/PGC-1α and JAK2/STAT3 signaling pathway in rats
MS El-Ghannam, MA Saad, NN Nassar… - Toxicology and Applied …, 2022 - Elsevier
Ulcerative colitis is a chronic inflammatory disease, profoundly affecting the patient's quality
of life and is associated with various complications. Linagliptin, a potent DPP-IV inhibitor …
of life and is associated with various complications. Linagliptin, a potent DPP-IV inhibitor …
[HTML][HTML] Acrylamide exposure aggravates the development of ulcerative colitis in mice through activation of NF-κB, inflammatory cytokines, iNOS, and oxidative stress
K Amirshahrokhi - Iranian Journal of Basic Medical Sciences, 2021 - ncbi.nlm.nih.gov
Objective (s): Acrylamide is a toxic compound that forms during food processing at high
temperatures. Acrylamide has been shown to induce toxicity in various organs in the body …
temperatures. Acrylamide has been shown to induce toxicity in various organs in the body …
Simvastatin mitigates depressive-like behavior in ovariectomized rats: Possible role of NLRP3 inflammasome and estrogen receptors' modulation
ET Menze, H Ezzat, S Shawky, M Sami… - International …, 2021 - Elsevier
It is well known that females are more vulnerable than males to stress-related psychiatric
disorders, particularly during perimenopausal and postmenopausal periods. Hormone …
disorders, particularly during perimenopausal and postmenopausal periods. Hormone …
Graviola mitigates acetic acid–induced ulcerative colitis in rats: insight on apoptosis and Wnt/Hh signaling crosstalk
MG Helal, AG Abd Elhameed - Environmental Science and Pollution …, 2021 - Springer
In this study, we elucidated the potential protective effects of graviola leaves, compared with
sulfasalazine, against acetic acid (AA)–induced ulcerative colitis (UC) in rats. Twenty-eight …
sulfasalazine, against acetic acid (AA)–induced ulcerative colitis (UC) in rats. Twenty-eight …