The blood-brain barrier in aging and neurodegeneration

EG Knox, MR Aburto, G Clarke, JF Cryan… - Molecular …, 2022 - nature.com
The blood-brain barrier (BBB) is vital for maintaining brain homeostasis by enabling an
exquisite control of exchange of compounds between the blood and the brain parenchyma …

[HTML][HTML] Western diet as a trigger of Alzheimer's disease: From metabolic syndrome and systemic inflammation to neuroinflammation and neurodegeneration

A Więckowska-Gacek, A Mietelska-Porowska… - Ageing research …, 2021 - Elsevier
An excess of saturated fatty acids and simple sugars in the diet is a known environmental
risk factor of Alzheimer's disease (AD) but the holistic view of the interacting processes …

[HTML][HTML] Reaction of human monoclonal antibodies to SARS-CoV-2 proteins with tissue antigens: implications for autoimmune diseases

A Vojdani, E Vojdani, D Kharrazian - Frontiers in Immunology, 2021 - frontiersin.org
We sought to determine whether immune reactivity occurs between anti-SARS-CoV-2
protein antibodies and human tissue antigens, and whether molecular mimicry between …

Structure, function, and regulation of the blood-brain barrier tight junction in central nervous system disorders

JJ Lochhead, J Yang, PT Ronaldson… - Frontiers in physiology, 2020 - frontiersin.org
The blood-brain barrier (BBB) allows the brain to selectively import nutrients and energy
critical to neuronal function while simultaneously excluding neurotoxic substances from the …

[HTML][HTML] Prebiotic effect of dietary polyphenols: A systematic review

AM Alves-Santos, CSA Sugizaki, GC Lima… - Journal of Functional …, 2020 - Elsevier
Prebiotics are substrates selectively metabolized by hindgut microorganisms conferring
health benefits. Recent studies suggest polyphenols as candidate to prebiotics. Thus, this …

[HTML][HTML] Factors influencing the blood-brain barrier permeability

Y Zhao, L Gan, L Ren, Y Lin, C Ma, X Lin - Brain research, 2022 - Elsevier
The blood-brain barrier (BBB) is a dynamic structure that protects the brain from harmful
blood-borne, endogenous and exogenous substances and maintains the homeostatic …

Cellular rejuvenation: molecular mechanisms and potential therapeutic interventions for diseases

S Ji, M Xiong, H Chen, Y Liu, L Zhou, Y Hong… - … and Targeted Therapy, 2023 - nature.com
The ageing process is a systemic decline from cellular dysfunction to organ degeneration,
with more predisposition to deteriorated disorders. Rejuvenation refers to giving aged cells …

Blood-brain barrier dysfunction in normal aging and neurodegeneration: mechanisms, impact, and treatments

AV Andjelkovic, M Situ, AF Citalan-Madrid… - Stroke, 2023 - Am Heart Assoc
Cerebral endothelial cells and their linking tight junctions form a unique, dynamic and multi-
functional interface, the blood-brain barrier (BBB). The endothelium is regulated by …

Correlated evolution of social organization and lifespan in mammals

P Zhu, W Liu, X Zhang, M Li, G Liu, Y Yu, Z Li… - Nature …, 2023 - nature.com
Discerning the relationship between sociality and longevity would permit a deeper
understanding of how animal life history evolved. Here, we perform a phylogenetic …

In vivo methods for imaging blood–brain barrier function and dysfunction

WJ Harris, MC Asselin, R Hinz, LM Parkes… - European journal of …, 2023 - Springer
The blood–brain barrier (BBB) is the interface between the central nervous system and
systemic circulation. It tightly regulates what enters and is removed from the brain …