Macromolecular crystallography at synchrotron sources has proven to be the most influential
method within structural biology, producing thousands of structures since its inception. While …

iMOSFLM is a graphical user interface to the diffraction data-integration program MOSFLM. It
is designed to simplify data processing by dividing the process into a series of steps, which …

Oncogenic activation of BRAF fuels cancer growth by constitutively promoting RAS-
independent mitogen-activated protein kinase (MAPK) pathway signalling. Accordingly, RAF …

The new European X-ray Free-Electron Laser is the first X-ray free-electron laser capable of
delivering X-ray pulses with a megahertz inter-pulse spacing, more than four orders of …

xia2 is an expert system for the automated reduction of macromolecular crystallography
(MX) data employing well trusted existing software. The system can process a full MX data …

The emerging technique of serial X-ray diffraction, in which diffraction data are collected
from samples flowing across a pulsed X-ray source at repetition rates of 100 Hz or higher …

The method of molecular structure determination by X-ray crystallography is a little over a
century old. The history is described briefly, along with developments in X-ray sources and …

Shotgun scanning combinatorial mutagenesis was used to study the antigen-binding site of
Fab2C4, a humanized monoclonal antibody fragment that binds to the extracellular domain …

Processing diffraction data falls naturally into three distinct steps: First, determining an initial
estimate of the unit cell and orientation of the crystal; second, obtaining refined values for …

Robust generation of IgG bispecific antibodies has been a long-standing challenge. Existing
methods require extensive engineering of each individual antibody, discovery of common …