Planar cell polarity (PCP) is an essential feature of animal tissues, whereby distinct polarity
is established within the plane of a cell sheet. Tissue-wide establishment of PCP is driven by …

A long-term aim of the life sciences is to understand how organismal shape is encoded by
the genome. An important challenge is to identify mechanistic links between the genes that …

Organoids derived from human pluripotent stem cells are a potentially powerful tool for high-
throughput screening (HTS), but the complexity of organoid cultures poses a significant …

Elongation of the head-to-tail body axis by convergent extension is a conserved
developmental process throughout metazoans. In Drosophila, patterns of transcription factor …

The actin motor protein non-muscle myosin II (NMII) acts as a master regulator of cell
morphology, with a role in several essential cellular processes, including cell migration and …

WNT ligands induce Ca2+ signalling on target cells. PKD1 (polycystin 1) is considered an
orphan, atypical G-protein-coupled receptor complexed with TRPP2 (polycystin 2 or PKD2) …

The function of normal and defective candidate genes for human genetic diseases, which
are rapidly being identified in large numbers by human geneticists and the biomedical …

The mechanisms of tissue convergence and extension (CE) driving axial elongation in
mammalian embryos, and in particular, the cellular behaviors underlying CE in the epithelial …

Cell motility is a widespread biological property that is best understood in the context of
individual cell migration. Indeed, studies of migration in culture have provided tremendous …

Animal development requires a carefully orchestrated cascade of cell fate specification
events and cellular movements. A surprisingly small number of choreographed cellular …