The discovery of microRNAs (miRNAs) almost two decades ago established a new
paradigm of gene regulation. During the past ten years these tiny non-coding RNAs have …

Many studies have highlighted the role that microRNAs have in physiological processes and
how their deregulation can lead to cancer. More recently, it has been proposed that the …

The fine detail provided by sequencing-based transcriptome surveys suggests that RNA-seq
is likely to become the platform of choice for interrogating steady state RNA. In order to …

Micro RNA s (mi RNA s) have emerged as important regulators in the post‐transcriptional
control of gene expression. The discovery of their presence not only in tissues but also in …

In recent years, microRNAs (miRNAs) have been identified as mediators of tumour
suppression and stress responses exerted by the p53 tumour suppressor. p53-regulated …

MicroRNAs (miRNAs) are small regulatory RNAs that derive from distinctive hairpin
transcripts. To learn more about the miRNAs of mammals, we sequenced 60 million small …

The development of deep sequencing has enabled the identification of novel microRNAs
(miRNAs), leading to a growing appreciation for the fact that individual miRNAs can be …

Transcriptome analysis has been a key area of biological inquiry for decades. Over the
years, research in the field has progressed from candidate gene-based detection of RNAs …

Acute myeloid leukemia (AML) is a deadly hematologic malignancy characterized by the
uncontrolled growth of immature myeloid cells. Over the past several decades, we have …

Modification of microRNA sequences by the 3′ addition of nucleotides to generate so-
called “isomiRs” adds to the complexity of miRNA function, with recent reports showing that …