Antibiotic-resistant Mycobacterium tuberculosis strains are threatening progress in
containing the global tuberculosis epidemic. Mycobacterium tuberculosis is intrinsically …

Tuberculosis (TB) is a global infectious threat that is intensified by an increasing incidence of
highly drug-resistant disease. Whole-genome sequencing (WGS) studies of Mycobacterium …

The increasing incidence of drug resistance in Mycobacterium tuberculosis has diminished
the efficacy of almost all available antibiotics, complicating efforts to combat the spread of …

Featured Application This comprehensive overview of drug-resistant tuberculosis will be
useful for researchers to expand their knowledge beyond mechanisms other than …

Rationale: Carbapenems are recommended for treatment of drug-resistant tuberculosis.
Optimal dosing remains uncertain. Objectives: To evaluate the 14-day bactericidal activity of …

Mycobacterium tuberculosis causes tuberculosis, a disease that kills over 1 million people
each year. Its cell envelope is a common antibiotic target and has a unique structure due, in …

Abstract β-Lactam, commonly referred as azetidin-2-one, is a multifunctional building block
for synthesizing β-amino ketones, γ-amino alcohols, and other compounds. Besides its well …

Increasing evidence supports the repositioning of beta-lactams for tuberculosis (TB) therapy,
but further research on their interaction with conventional anti-TB agents is still warranted …

The lack of effective therapeutics against emerging multi-drug resistant strains of
Mycobacterium tuberculosis (Mtb) prompts the identification of novel anti-tuberculosis …

Multi-and extensively drug-resistant tuberculosis (M/XDR-TB) has become an increasing
threat not only in countries where the TB burden is high but also in affluent regions, due to …