Most human genes encode multiple mRNA variants and protein products through alternative
splicing of exons and introns during pre-mRNA processing. In this way, alternative splicing …

Autophagy and RNA alternative splicing are two evolutionarily conserved processes
involved in overlapping physiological and pathological processes. However, the extent of …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Mitochondria are critical metabolic and signaling hubs, and dysregulated mitochondrial
homeostasis is implicated in many diseases. Degradation of damaged mitochondria by …

Alternative splicing is a critical process to generate protein diversity. However, whether and
how alternative splicing regulates autophagy remains largely elusive. Here we …

Macroautophagy/autophagy functions as a part of the innate immune system in clearing
intracellular pathogens. Although this process is well known, the mechanisms that control …

Beclin-1 is the firstly-identified mammalian protein of the autophagy machinery, which
functions as a molecular scaffold for the assembly of PI3KC3 (class III phosphatidylinositol 3 …

Autophagy plays a double‐edged sword for cancer; particularly, mitophagy plays important
roles in the selective degradation of damaged mitochondria. However, whether mitophagy is …

Pulmonary hypertension is characterized by pulmonary arterial remodeling that results in
increased pulmonary vascular resistance, right ventricular failure, and premature death. It is …

Autophagy is a well-known cellular process involved in many physiological and pathological
processes. During erythropoiesis, autophagy plays an important role participating in the …