Abstract Calcium (Ca 2+) is an universal second messenger that regulates the most
important activities of all eukaryotic cells. It is of critical importance to neurons as it …

Endosomes, lysosomes and lysosome-related organelles are emerging as important Ca2+
storage cellular compartments with a central role in intracellular Ca2+ signalling …

A proper dialogue between spermatozoa and the egg is essential for conception of a new
individual in sexually reproducing animals. Ca2+ is crucial in orchestrating this unique event …

Voltage-gated calcium channels (VGCCs) comprise five subtypes: The L‑type; R‑type; N‑
type; P/Q‑type; and T‑type, which are encoded by α1 subunit genes. Calcium ion channels …

The ionic nature of endosomes varies considerably in character along the endocytic
pathway. Counter‐ion flux across the limiting membrane of endosomes has long been …

Nicotinic acid adenine dinucleotide phosphate (NAADP) is a molecule capable of initiating
the release of intracellular Ca 2+ required for many essential cellular processes. Recent …

Voltage-gated Na+-permeable (Nav) channels form the basis for electrical excitability in
animals. Nav channels evolved from Ca2+ channels and were present in the common …

In the past years, several hereditary diseases caused by defects in transient receptor
potential channels (TRP) genes have been described. This review summarizes our current …

Melanosomes are unique organelles in melanocytes that produce melanin, the pigment for
skin, hair, and eye color. Tyrosinase is the essential and rate-limiting enzyme for melanin …

J. Neurochem.(2010) 113, 313–328. Abstract Ion channels are classically understood to
regulate the flux of ions across the plasma membrane in response to a variety of …