Mechanisms of human telomerase reverse transcriptase (hTERT) regulation: clinical impacts in cancer
Background Limitless self-renewal is one of the hallmarks of cancer and is attained by
telomere maintenance, essentially through telomerase (h TERT) activation. Transcriptional …
telomere maintenance, essentially through telomerase (h TERT) activation. Transcriptional …
Finding the end: recruitment of telomerase to telomeres
J Nandakumar, TR Cech - Nature reviews Molecular cell biology, 2013 - nature.com
Telomeres, the ends of linear eukaryotic chromosomes, are characterized by the presence
of multiple repeats of a short DNA sequence. This telomeric DNA is protected from illicit …
of multiple repeats of a short DNA sequence. This telomeric DNA is protected from illicit …
Telomerase promoter mutations in cancer: an emerging molecular biomarker?
Cell immortalization has been considered for a long time as a classic hallmark of cancer
cells. Besides telomerase reactivation, such immortalization could be due to telomere …
cells. Besides telomerase reactivation, such immortalization could be due to telomere …
It all comes together at the ends: telomerase structure, function, and biogenesis
JD Podlevsky, JJL Chen - Mutation Research/Fundamental and Molecular …, 2012 - Elsevier
Telomerase is a reverse transcriptase specialized in the addition of telomeric DNA repeats
onto the ends of chromosomes. Telomere extension offsets the loss of telomeric repeats …
onto the ends of chromosomes. Telomere extension offsets the loss of telomeric repeats …
[HTML][HTML] Transient delivery of modified mRNA encoding TERT rapidly extends telomeres in human cells
Telomere extension has been proposed as a means to improve cell culture and tissue
engineering and to treat disease. However, telomere extension by nonviral, nonintegrating …
engineering and to treat disease. However, telomere extension by nonviral, nonintegrating …
TERT biology and function in cancer: beyond immortalisation
A Pestana, J Vinagre… - Journal of molecular …, 2017 - jme.bioscientifica.com
Evasion of replicative senescence and proliferation without restriction, sometimes
designated as immortalisation, is one of the hallmarks of cancer that may be attained …
designated as immortalisation, is one of the hallmarks of cancer that may be attained …
miR-1207-5p and miR-1266 suppress gastric cancer growth and invasion by targeting telomerase reverse transcriptase
L Chen, MH Lü, D Zhang, NB Hao, YH Fan… - Cell death & …, 2014 - nature.com
Abstract hTERT is the catalytic subunit of the telomerase complex. Elevated expression of
hTERT is associated with the expansion and metastasis of gastric tumor. In this study, we …
hTERT is associated with the expansion and metastasis of gastric tumor. In this study, we …
TRIP4 promotes tumor growth and metastasis and regulates radiosensitivity of cervical cancer by activating MAPK, PI3K/AKT, and hTERT signaling
Y Che, Y Li, F Zheng, K Zou, Z Li, M Chen, S Hu, C Tian… - Cancer letters, 2019 - Elsevier
Thyroid hormone receptor interactor 4 (TRIP4), a subunit of the tetrameric nuclear activating
signal co-integrator 1 (ASC-1) complex, exerts pro-tumorigenic effects. The role for TRIP4 in …
signal co-integrator 1 (ASC-1) complex, exerts pro-tumorigenic effects. The role for TRIP4 in …
Mechanisms of telomerase inhibition by oxidized and therapeutic dNTPs
SL Sanford, GA Welfer, BD Freudenthal… - Nature …, 2020 - nature.com
Telomerase is a specialized reverse transcriptase that adds GGTTAG repeats to
chromosome ends and is upregulated in most human cancers to enable limitless …
chromosome ends and is upregulated in most human cancers to enable limitless …
TERT Promoter Mutations in Thyroid Cancer
Two mutations (C228T and C250T) in the promoter region of the telomerase reverse
transcriptase (TERT) have recently been described in different types of cancer including …
transcriptase (TERT) have recently been described in different types of cancer including …