Transactive response DNA binding protein (TDP-43) is a key player in neurodegenerative
diseases. In this review, we have gathered and presented structural information on the …

Mutations in the 43 kDa transactive-response (TAR)-DNA-binding protein (TARDBP) are
associated with 2–5% of familial Amyotrophic Lateral Sclerosis (ALS) cases. TAR DNA …

Insoluble inclusions of phosphorylated TDP-43 occur in disease-affected neurons of most
patients with amyotrophic lateral sclerosis (ALS) and about half of patients with …

A common pathological denominator of various neurodegenerative diseases is the
accumulation of protein aggregates. Neurotoxic effects are caused by a loss of the …

Abstract The TAR DNA Binding Protein 43 (TDP-43) has been implicated in the
pathogenesis of human neurodegenerative diseases and exhibits hallmark neuropathology …

The aggregation of RNA binding proteins, including hnRNPA1/2, TDP-43 and FUS, is
heavily implicated in causing or increasing disease risk for a series of neurodegenerative …

Aggregation of hyperphosphorylated TDP-43 is the hallmark pathological feature of the most
common molecular form of frontotemporal lobar degeneration (FTLD–TDP) and in the vast …

The aggregation of TAR DNA-binding protein of 43 kDa (TDP-43) into fibrillary deposits is
implicated in amyotrophic lateral sclerosis (ALS), and some hereditary mutations localized in …

Pathogenic mutations of transactivation response element DNA-binding protein 43 (TDP-43)
are closely linked with amyotrophic lateral sclerosis (ALS). It was recently reported that two …

TAR DNA-binding protein 43 (TDP-43) is a nucleic acid–binding protein found in the
nucleus that accumulates in the cytoplasm under pathological conditions, leading to …