The fifth edition of the World Health Organization (WHO) classification of urogenital tumours
(WHO “Blue Book”), published in 2022, contains significant revisions. This review …

Abstract The Genitourinary Pathology Society (GUPS) undertook a critical review of the
recent advances in renal neoplasia, particularly focusing on the newly accumulated …

Abstract The Genitourinary Pathology Society (GUPS) reviewed recent advances in renal
neoplasia, particularly post-2016 World Health Organization (WHO) classification, to provide …

Tuberous sclerosis complex (TSC) is an autosomal dominant disorder that affects multiple
organ systems and is caused by loss-of-function mutations in one of two genes: TSC1 or …

Context International variations in the rates of kidney cancer (KC) are considerable. An
understanding of the risk factors for KC development is necessary to generate opportunities …

Abstract Tuberous Sclerosis Complex (TSC) is caused by TSC1 or TSC2 mutations,
resulting in hyperactivation of the mechanistic target of rapamycin complex 1 (mTORC1) …

Purpose Pathological parameters assessed on biopsies and resection specimens have a
pivotal role in the diagnosis, prognosis and management of patients with renal cell …

Accumulating evidence suggests that renal cell tumors represent a group of histologically
and molecularly heterogeneous diseases, even within the same histological subtype. In …

A distinct renal tumor has recently been described as “high-grade oncocytic renal tumor”
and “sporadic renal cell carcinoma with eosinophilic and vacuolated cytoplasm”. The …

Renal tumours include a heterogeneous and diverse spectrum of neoplasms. Recent
advances in this field have significantly improved our understanding of the morphological …