Abstract Calcium (Ca2+) signalling is of paramount importance to immunity. Regulated
increases in cytosolic and organellar Ca2+ concentrations in lymphocytes control complex …

Ion channels and transporters mediate the transport of charged ions across hydrophobic
lipid membranes. In immune cells, divalent cations such as calcium, magnesium, and zinc …

Lymphocyte function is regulated by a network of ion channels and transporters in the
plasma membrane of B and T cells. These proteins modulate the cytoplasmic concentrations …

Calcium signals in cells of the immune system participate in the regulation of cell
differentiation, gene transcription and effector functions. An increase in intracellular levels of …

The L-type Cav1. 2 calcium channel is present throughout the animal kingdom and is
essential for some aspects of CNS function, cardiac and smooth muscle contractility …

The voltage-gated calcium channel α2δ and β subunits are traditionally considered to be
auxiliary subunits that enhance channel trafficking, increase the expression of functional …

For more than 25 years, it has been widely appreciated that Ca2+ influx is essential to
trigger T‐lymphocyte activation. Patch clamp analysis, molecular identification, and …

Ca2+ entry into cells of the peripheral immune system occurs through highly Ca2+-selective
channels known as CRAC (calcium release-activated calcium) channels. CRAC channels …

Calcium regulates a wide spectrum of physiological processes such as heartbeat, muscle
contraction, neuronal communication, hormone release, cell division, and gene …

Calcium acts as a second messenger in many cell types, including lymphocytes. Resting
lymphocytes maintain a low concentration of Ca2+. However, engagement of antigen …