The protein kinase, GSK-3, participates in diverse biological processes and is now
recognized a promising drug discovery target in treating multiple pathological conditions …

Neurogenic regions of mammalian brain produce many more neurons that will eventually
survive and reach a mature stage. Developmental cell death affects both embryonically …

Background CDKL5 deficiency disorder (CDD) is a rare, X-linked, developmental and
epileptic encephalopathy characterised by severe global developmental impairment and …

Enhancing neurogenesis within the hippocampal dentate gyrus (DG) is critical for
maintaining brain development and function in many neurological diseases. However, the …

CDKL5 deficiency disorder (CDD) is a complex of clinical symptoms resulting from the
presence of non-functional CDKL5 protein, ie, serine-threonine kinase (previously referred …

Early-onset epileptic encephalopathies are severe disorders often associated with specific
genetic mutations. In this context, the CDKL5 deficiency disorder (CDD) is a …

Mutations in the Cyclin-dependent kinase-like 5 (CDKL5) gene cause severe
neurodevelopmental disorders accompanied by intractable epilepsies, ie West syndrome or …

Autism spectrum disorder (ASD) comprises a range of neurological conditions that affect
individuals' ability to communicate and interact with others. People with ASD often exhibit …

CDKL5 deficiency disorder (CDD) is an X-linked brain disorder of young children and is
caused by pathogenic variants in the cyclin-dependent kinase-like 5 (CDKL5) gene …

The X‐linked gene cyclin‐dependent kinase‐like 5 (CDKL5) encodes a serine/threonine
kinase abundantly expressed in the brain. Mutations in CDKL5 have been associated with …