Recent advances in covalent drug discovery
D Schaefer, X Cheng - Pharmaceuticals, 2023 - mdpi.com
In spite of the increasing number of biologics license applications, the development of
covalent inhibitors is still a growing field within drug discovery. The successful approval of …
covalent inhibitors is still a growing field within drug discovery. The successful approval of …
Characteristics of food protein-derived antidiabetic bioactive peptides: A literature update
NTP Nong, JL Hsu - International Journal of Molecular Sciences, 2021 - mdpi.com
Diabetes, a glucose metabolic disorder, is considered one of the biggest challenges
associated with a complex complication of health crises in the modern lifestyle. Inhibition or …
associated with a complex complication of health crises in the modern lifestyle. Inhibition or …
Bioactive peptides: An understanding from current screening methodology
NTP Nong, JL Hsu - Processes, 2022 - mdpi.com
Bioactive peptides with high potency against numerous human disorders have been
regarded as a promising therapy in disease control. These peptides could be released from …
regarded as a promising therapy in disease control. These peptides could be released from …
Integration of in vitro and in silico approaches to assess three Astragalus species from Turkey flora: A novel spotlight from lab bench to functional applications
Members of the genus Astragalus have a great interest as a source of natural bioactive
compounds on a scientific platform. To provide multidirectional insights into three Astragalus …
compounds on a scientific platform. To provide multidirectional insights into three Astragalus …
A multifunctional key to open a new window on the path to natural resources-lessons from a study on chemical composition and biological capability of Paeonia …
The genus Paeonia has gained great interest from the scientific community for exploration
as a source of bioactive compounds. The current work focused on the chemical …
as a source of bioactive compounds. The current work focused on the chemical …
Comprehensive evaluation of two Astragalus species (A. campylosema and A. hirsutus) based on biological, toxicological properties and chemical profiling
Astragalus L.(Fabaceae) is an important genus with numerous species having various
traditional medicinal uses making them of interest for scientific investigations to ascertain …
traditional medicinal uses making them of interest for scientific investigations to ascertain …
Antioxidant activity and inhibitory effect of curcumin on some enzymes involved in several diseases: acetylcholinesterase, butyrylcholinesterase, α-glucosidase and …
Aim: This study investigates the potential effect of pure curcumin on the inhibition of different
enzymes involved in several diseases. Background: Several chronic diseases such as …
enzymes involved in several diseases. Background: Several chronic diseases such as …
Angiotensin converting enzyme (ACE) inhibitors activity from purified compounds Fructus Phaleria macrocarpa (Scheff) Boerl
Abstract Background Mahkota Dewa [Phaleria macrocarpa (Scheff) Boerl.] fruit in vitro and in-
vivo can decrease and prevent elevation of the blood pressure, lower plasma glucose …
vivo can decrease and prevent elevation of the blood pressure, lower plasma glucose …
Phytochemical Constituents and Biological Activities of the Unexplored Plant Rhinanthus angustifolius subsp. grandiflorus
In the present study, a total of 12 extracts of Rhinanthus angustifolius subsp. grandiflorus, an
understudied hemiparasitic species, were obtained using different extraction techniques …
understudied hemiparasitic species, were obtained using different extraction techniques …
Comprehensive Biological and Chemical Evaluation of Two Seseli Species (S. gummiferum and S. transcaucasicum)
Seseli L. is one of the largest genera of the Apiaceae family widely known for their traditional
uses as herbal remedies. In the present study, the methanolic and water extracts of two …
uses as herbal remedies. In the present study, the methanolic and water extracts of two …