The controversial role of HCY and vitamin B deficiency in cardiovascular diseases

W Herrmann, M Herrmann - Nutrients, 2022 - mdpi.com
Plasma homocysteine (HCY) is an established risk factor for cardiovascular disease CVD
and stroke. However, more than two decades of intensive research activities has failed to …

Implications of plasma thiol redox in disease

PVS Oliveira, FRM Laurindo - Clinical Science, 2018 - portlandpress.com
Thiol groups are crucially involved in signaling/homeostasis through oxidation, reduction,
and disulphide exchange. The overall thiol pool is the resultant of several individual pools of …

Paraoxonase-1 as a regulator of glucose and lipid homeostasis: impact on the onset and progression of metabolic disorders

MJ Meneses, R Silvestre, I Sousa-Lima… - International journal of …, 2019 - mdpi.com
Metabolic disorders are characterized by an overall state of inflammation and oxidative
stress, which highlight the importance of a functional antioxidant system and normal activity …

Phenolic compounds exerting lipid-regulatory, anti-inflammatory and epigenetic effects as complementary treatments in cardiovascular diseases

L Toma, GM Sanda, LS Niculescu, M Deleanu… - Biomolecules, 2020 - mdpi.com
Atherosclerosis is the main process behind cardiovascular diseases (CVD), maladies which
continue to be responsible for up to 70% of death worldwide. Despite the ongoing …

High-throughput optical assays for sensing serine hydrolases in living systems and their applications

Q Jin, LL Song, LL Ding, J Zhang, DD Wang… - TrAC Trends in …, 2022 - Elsevier
Serine hydrolases (SHs) comprise a large family of hydrolytic enzymes that play crucial roles
in numerous physiological and pathological processes, such as blood coagulation, cancer …

Paraoxonases activities and polymorphisms in elderly and old-age diseases: An overview

D Levy, CO Reichert, SP Bydlowski - Antioxidants, 2019 - mdpi.com
Aging is defined as the accumulation of progressive organ dysfunction. There is much
evidence linking the involvement of oxidative stress in the pathogenesis of aging. With …

Paraoxonase-1 genetic polymorphisms in organophosphate metabolism

E Dardiotis, AM Aloizou, V Siokas, Z Tsouris, D Rikos… - Toxicology, 2019 - Elsevier
Organophosphates (OPs) are a class of chemicals commonly used in agriculture as
pesticides, that can often lead to severe toxicity in humans. Paraoxonase-1 (PON1) belongs …

Why should psychiatrists and neuroscientists worry about paraoxonase 1?

EG Moreira, KM Boll, DG Correia… - Current …, 2019 - ingentaconnect.com
Background: Nitro-oxidative stress (NOS) has been implicated in the pathophysiology of
psychiatric disorders. The activity of the polymorphic antioxidant enzyme paraoxonase 1 …

Effects of combined physical exercise on plasma lipid variables, paraoxonase 1 activity, and inflammation parameters in adults with obesity: a randomized clinical trial

AR Streb, PGS Braga, RF de Melo, LJ Botelho… - Journal of …, 2022 - Springer
Objective We aimed to investigate whether combined physical exercise may affect plasma
lipid variables, paraoxonase 1 (PON1) activity, and inflammation parameters in adults with …

The Impact of Punica granatum Linn and Its Derivatives on Oxidative Stress, Inflammation, and Endothelial Function in Diabetes Mellitus: Evidence from Preclinical …

K Mokgalaboni, S Dlamini, WN Phoswa, P Modjadji… - Antioxidants, 2023 - mdpi.com
Diabetes mellitus is recognized as the leading contributor to cardiovascular disease and
associated mortality rates worldwide. Despite the use of pharmaceutical drugs to treat …