Re-engineering extracellular vesicles as smart nanoscale therapeutics

JPK Armstrong, MN Holme, MM Stevens - ACS nano, 2017 - ACS Publications
In the past decade, extracellular vesicles (EVs) have emerged as a key cell-free strategy for
the treatment of a range of pathologies, including cancer, myocardial infarction, and …

Extracellular vesicles: biology and emerging therapeutic opportunities

S El Andaloussi, I Mäger, XO Breakefield… - Nature reviews Drug …, 2013 - nature.com
Within the past decade, extracellular vesicles have emerged as important mediators of
intercellular communication, being involved in the transmission of biological signals …

Enhanced therapeutic effects of mesenchymal stem cell-derived exosomes with an injectable hydrogel for hindlimb ischemia treatment

K Zhang, X Zhao, X Chen, Y Wei, W Du… - … applied materials & …, 2018 - ACS Publications
Mesenchymal stem cell (MSC)-derived exosomes have been recognized as new candidates
for cell-free treatment of various diseases. However, maintaining the retention and stability of …

Supramolecular nanofibers containing arginine-glycine-aspartate (RGD) peptides boost therapeutic efficacy of extracellular vesicles in kidney repair

C Zhang, Y Shang, X Chen, AC Midgley, Z Wang… - ACS …, 2020 - ACS Publications
Extracellular vesicles (EVs) derived from mesenchymal stem cells (MSC-EVs) have been
recognized as a promising cell-free therapy for acute kidney injury (AKI), which avoids safety …

Electroporation-induced siRNA precipitation obscures the efficiency of siRNA loading into extracellular vesicles

SAA Kooijmans, S Stremersch, K Braeckmans… - Journal of Controlled …, 2013 - Elsevier
Extracellular vesicles (EVs) are specialised endogenous carriers of proteins and nucleic
acids and are involved in intercellular communication. EVs are therefore proposed as …

Exosomes for targeted siRNA delivery across biological barriers

SEL Andaloussi, S Lakhal, I Mäger… - Advanced drug delivery …, 2013 - Elsevier
Using oligonucleotide-based drugs to modulate gene expression has opened a new avenue
for drug discovery. In particular small interfering RNAs (siRNAs) are being rapidly …

Focus on extracellular vesicles: physiological role and signalling properties of extracellular membrane vesicles

N Iraci, T Leonardi, F Gessler, B Vega… - International journal of …, 2016 - mdpi.com
Extracellular vesicles (EVs) are a heterogeneous population of secreted membrane
vesicles, with distinct biogenesis routes, biophysical properties and different functions both …

[HTML][HTML] The stem cell secretome and its role in brain repair

D Drago, C Cossetti, N Iraci, E Gaude, G Musco… - Biochimie, 2013 - Elsevier
Compelling evidence exists that non-haematopoietic stem cells, including mesenchymal
(MSCs) and neural/progenitor stem cells (NPCs), exert a substantial beneficial and …

Concise review: mesenchymal stem cells in neurodegenerative diseases

R Volkman, D Offen - Stem cells, 2017 - academic.oup.com
Stem cell-based therapies for neurodegenerative diseases aim at halting clinical
deterioration by regeneration and by providing local support for damaged tissue …

Mesenchymal stem cell-based nanoparticles and scaffolds in regenerative medicine

PK Raghav, Z Mann, S Ahlawat, S Mohanty - European journal of …, 2022 - Elsevier
Mesenchymal stem cells (MSCs) are adult stem cells owing to their regenerative potential
and multilineage potency. MSCs have wide-scale applications either in their native cellular …