Toll‐like receptors (TLRs): structure, functions, signaling, and role of their polymorphisms in colorectal cancer susceptibility

AS Sameer, S Nissar - BioMed Research International, 2021 - Wiley Online Library
Toll‐like receptors (TLRs) are the important mediators of inflammatory pathways in the gut
which play a major role in mediating the immune responses towards a wide variety of …

Inflammation-induced tumorigenesis and metastasis

S Hibino, T Kawazoe, H Kasahara, S Itoh… - International journal of …, 2021 - mdpi.com
Inflammation, especially chronic inflammation, plays a pivotal role in tumorigenesis and
metastasis through various mechanisms and is now recognized as a hallmark of cancer and …

The inflammatory microenvironment and microbiome in prostate cancer development

KS Sfanos, S Yegnasubramanian, WG Nelson… - Nature Reviews …, 2018 - nature.com
Chronic inflammation promotes the development of several types of solid cancers and might
contribute to prostate carcinogenesis. This hypothesis partly originates in the frequent …

[HTML][HTML] Toll-like receptor signaling in colorectal cancer: carcinogenesis to cancer therapy

TT Li, S Ogino, ZR Qian - World journal of gastroenterology: WJG, 2014 - ncbi.nlm.nih.gov
Toll-like receptors (TLRs) are germ line encoded innate immune sensors that recognize
conserved microbial structures and host alarmins, and signal expression of major …

The present and future of biomarkers in prostate cancer: proteomics, genomics, and immunology advancements: supplementary issue: biomarkers and their essential …

PO Gaudreau, J Stagg, D Soulières… - Biomarkers in …, 2016 - journals.sagepub.com
Prostate cancer (PC) is the second most common form of cancer in men worldwide.
Biomarkers have emerged as essential tools for treatment and assessment since the …

The pathologic role of toll-like receptor 4 in prostate cancer

T Ou, M Lilly, W Jiang - Frontiers in immunology, 2018 - frontiersin.org
Toll-like receptor (TLR) 4 is expressed on normal and malignant prostate epithelial cells.
The TLR4 and its downstream signaling pathways mediate innate immune responses in the …

The molecular basis and clinical consequences of chronic inflammation in prostatic diseases: prostatitis, benign prostatic hyperplasia, and prostate Cancer

SO Oseni, C Naar, M Pavlović, W Asghar, JX Hartmann… - Cancers, 2023 - mdpi.com
Simple Summary In this review paper, we explore the role of chronic inflammation in the
pathogenesis of prostatic diseases, such as chronic prostatitis, benign prostatic hyperplasia …

Expression and polymorphism of toll-like receptor 4 and effect on NF-κB mediated inflammation in colon cancer patients

A Semlali, N Reddy Parine, M Arafah, L Mansour… - PloS one, 2016 - journals.plos.org
Our aim was to evaluate the association between the expression and the polymorphism of
TLR4/NF-κB pathways and colon cancer. TLR4 (rs4986790, rs10759932, rs10759931 and …

Expression analysis of inflammasome sensors and implication of NLRP12 inflammasome in prostate cancer

D Karan, O Tawfik, S Dubey - Scientific reports, 2017 - nature.com
Inflammasomes are multi-proteins complex regulating inflammation-associated signaling.
While inflammation plays a critical role in cancer cell growth, studies remain uncharacterized …

P. acnes-Driven Disease Pathology: Current Knowledge and Future Directions

JR Leheste, KE Ruvolo, JE Chrostowski… - Frontiers in cellular …, 2017 - frontiersin.org
This review discusses the biology and behavior of Propionibacterium acnes (P. acnes), a
dominant bacterium species of the skin biogeography thought to be associated with …