The role of cell death in SARS-CoV-2 infection

C Yuan, Z Ma, J Xie, W Li, L Su, G Zhang, J Xu… - Signal transduction and …, 2023 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), showing high
infectiousness, resulted in an ongoing pandemic termed coronavirus disease 2019 (COVID …

Co-exposure to molybdenum and cadmium evokes necroptosis and decreases apoptosis in duck myocardium

H Liu, X Dai, S Xu, H Guo, J Zhu, S Wang, Y Wu… - Science of The Total …, 2023 - Elsevier
Superfluous molybdenum (Mo) and cadmium (Cd) in the environment are detrimental to
organisms through their accumulation. The NF-κB/TNF-α axis plays a vital part in regulating …

Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2

Y Xue, H Mei, Y Chen, JD Griffin, Q Liu… - MedComm, 2023 - Wiley Online Library
Abstract The coronavirus disease 2019 (COVID‐19) pandemic has affected a large portion
of the global population, both physically and mentally. Current evidence suggests that the …

Self-DNA driven inflammation in COVID-19 and after mRNA-based vaccination: lessons for non-COVID-19 pathologies

M Heil - Frontiers in Immunology, 2024 - frontiersin.org
The coronavirus disease 2019 (COVID-19) pandemic triggered an unprecedented
concentration of economic and research efforts to generate knowledge at unequalled speed …

[HTML][HTML] Functional and structural investigation of a broadly neutralizing SARS-CoV-2 antibody

YH Chang, MF Hsu, WN Chen, MH Wu, WL Kong… - JCI insight, 2024 - ncbi.nlm.nih.gov
Since its emergence, SARS-CoV-2 has been continuously evolving, hampering the
effectiveness of current vaccines against COVID-19. mAbs can be used to treat patients at …

[HTML][HTML] SARS-CoV-2 evolves increased infection elicited cell death and fusion in an immunosuppressed individual

G Lustig, Y Ganga, H Rodel, H Tegally, L Jackson… - medRxiv, 2022 - ncbi.nlm.nih.gov
The milder clinical manifestations of Omicron infection relative to pre-Omicron SARS CoV-2
raises the possibility that extensive evolution results in reduced pathogenicity. To test this …

Comprehensive analysis of immunogenic cell death-related gene and construction of prediction model based on WGCNA and multiple machine learning in severe …

C Li, K Wu, R Yang, M Liao, J Li, Q Zhu, J Zhang… - Scientific Reports, 2024 - nature.com
The death of coronavirus disease 2019 (COVID-19) is primarily due to from critically ill
patients, especially from ARDS complications caused by SARS-CoV-2. Therefore, it is …

Cellular and molecular mechanisms of pathogenic and protective immune responses to SARS-CoV-2 and implications of COVID-19 vaccines

SMF Akbar, M Al Mahtab, S Khan - Vaccines, 2023 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has devastated
the world with coronavirus disease 2019 (COVID-19), which has imparted a toll of at least …

SS31 alleviates LPS-induced acute lung injury by inhibiting inflammatory responses through the S100A8/NLRP3/GSDMD signaling pathway

P Luo, Q Gu, J Wang, X Li, N Li, W Yang… - European Journal of …, 2024 - Springer
Background Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is an acute,
diffuse, inflammatory lung injury caused by various endogenous or exogenous factors. It is …

[HTML][HTML] Mechanisms of pulmonary endothelial barrier dysfunction in acute lung injury and acute respiratory distress syndrome

Y Su, R Lucas, DJR Fulton, AD Verin - Chinese Medical Journal Pulmonary …, 2024 - Elsevier
Endothelial cells (ECs) form a semi-permeable barrier between the interior space of blood
vessels and the underlying tissues. Pulmonary endothelial barrier integrity is maintained …