Over the past three decades, a considerable body of evidence has highlighted T cells as
pivotal culprits in the pathogenesis of psoriasis. This includes the association of psoriasis …

Autoimmune diseases, such as Systemic Lupus Erythematosus (SLE) or Rheumatoid
Arthritis (RA) are characterized by the breakdown of immunological tolerance. Defects of …

Psoriasis is a prevalent, chronic inflammatory disease of the skin, mediated by crosstalk
between epidermal keratinocytes, dermal vascular cells, and immunocytes such as antigen …

Since the characterization of CD4+ CD25+ regulatory T (Treg) cells in mice, significant
progress has been made in the definitions of the phenotype and the function of human Treg …

The immune system is designed to protect the host from infection and injury. However, when
an adaptive immune response continues unchecked in the brain, the proinflammatory innate …

Autoreactive B and T cells are present in healthy, autoimmunity-free individuals, but they are
kept in check by various regulatory mechanisms. In systemic lupus erythematosus (SLE) …

A primary function of B lymphocytes is immunoglobulin production; however, the therapeutic
benefit of B cell depletion in autoimmune diseases previously thought to be T cell mediated …

Previous studies have implicated that the transplantation of human umbilical cord
mesenchymal stem cells (hUC-MSCs) effectively alleviates systemic lupus erythematosus …

As one specialized subset of regulatory T cells (Tregs), follicular regulatory T cells (TFR)
could suppress follicular helper T cells (TFH) and B cells in germinal centers to maintain …

Objective: The high-mobility group box-1 protein (HMGB1) serves as the prototypic damage-
associated molecular pattern molecule, interacting with a variety of defined pattern …