DNA nanotechnology-enabled drug delivery systems

Q Hu, H Li, L Wang, H Gu, C Fan - Chemical reviews, 2018 - ACS Publications
Over the past decade, we have seen rapid advances in applying nanotechnology in
biomedical areas including bioimaging, biodetection, and drug delivery. As an emerging …

Bioinspired smart asymmetric nanochannel membranes

Z Zhang, L Wen, L Jiang - Chemical Society Reviews, 2018 - pubs.rsc.org
Bioinspired smart asymmetric nanochannel membranes (BSANM) have been explored
extensively to achieve the delicate ionic transport functions comparable to those of living …

Nanopore sensing

W Shi, AK Friedman, LA Baker - Analytical chemistry, 2017 - ACS Publications
Scope of the Review. Herein, we provide an up-to-date overview of the field of nanopore
sensing with emphases placed on the advances made in the most recent two years (2014 …

A biomimetic DNA-based channel for the ligand-controlled transport of charged molecular cargo across a biological membrane

JR Burns, A Seifert, N Fertig, S Howorka - Nature nanotechnology, 2016 - nature.com
Biological ion channels are molecular gatekeepers that control transport across cell
membranes. Recreating the functional principle of such systems and extending it beyond …

Building membrane nanopores

S Howorka - Nature nanotechnology, 2017 - nature.com
Membrane nanopores—hollow nanoscale barrels that puncture biological or synthetic
membranes—have become powerful tools in chemical-and biosensing, and have achieved …

Programmable and multifunctional DNA‐based materials for biomedical applications

Y Zhang, J Tu, D Wang, H Zhu, SK Maity… - Advanced …, 2018 - Wiley Online Library
DNA encodes the genetic information; recently, it has also become a key player in material
science. Given the specific Watson–Crick base‐pairing interactions between only four types …

A large size-selective DNA nanopore with sensing applications

RP Thomsen, MG Malle, AH Okholm, S Krishnan… - Nature …, 2019 - nature.com
Transmembrane nanostructures like ion channels and transporters perform key biological
functions by controlling flow of molecules across lipid bilayers. Much work has gone into …

Large-conductance transmembrane porin made from DNA origami

K Göpfrich, CY Li, M Ricci, SP Bhamidimarri, J Yoo… - ACS …, 2016 - ACS Publications
DNA nanotechnology allows for the creation of three-dimensional structures at nanometer
scale. Here, we use DNA to build the largest synthetic pore in a lipid membrane to date …

Oriented triplex DNA as a synthetic receptor for transmembrane signal transduction

H Chen, S Zhou, K Ngocho, J Zheng, X He… - Nature …, 2024 - nature.com
Signal transduction across biological membranes enables cells to detect and respond to
diverse chemical or physical signals, and replicating these complex biological processes …

Synthetic protein-conductive membrane nanopores built with DNA

T Diederichs, G Pugh, A Dorey, Y Xing… - Nature …, 2019 - nature.com
Nanopores are key in portable sequencing and research given their ability to transport
elongated DNA or small bioactive molecules through narrow transmembrane channels …