Back to the future: re-establishing guinea pig in vivo asthma models

M Adner, BJ Canning, H Meurs, W Ford… - Clinical …, 2020 - portlandpress.com
Research using animal models of asthma is currently dominated by mouse models. This has
been driven by the comprehensive knowledge on inflammatory and immune reactions in …

ACC-BLA functional connectivity disruption in allergic inflammation is associated with anxiety

L Gholami-Mahtaj, M Mooziri, K Dehdar… - Scientific Reports, 2022 - nature.com
Allergic asthma is a chronic inflammatory respiratory disease. Psychiatric disorders,
including anxiety are associated with poorer treatment response and disease control in …

Structure–activity relationship analysis of psychedelics in a rat model of asthma reveals the anti-inflammatory pharmacophore

TW Flanagan, GB Billac, AN Landry… - ACS Pharmacology & …, 2020 - ACS Publications
Psychedelic drugs can exert potent anti-inflammatory effects. However, anti-inflammatory
effects do not appear to correlate with behavioral activity, suggesting different underlying …

Allergen-induced anxiety-like behavior is associated with disruption of medial prefrontal cortex-amygdala circuit

K Dehdar, S Mahdidoust, M Salimi, L Gholami-Mahtaj… - Scientific reports, 2019 - nature.com
Anxiety is prevalent in asthma, and is associated with disease severity and poor quality of
life. However, no study to date provides direct experimental evidence for the effect of allergic …

Corticosteroid treatment attenuates anxiety and mPFC-amygdala circuit dysfunction in allergic asthma

K Dehdar, M Mooziri, AS Moghaddam, M Salimi… - Life Sciences, 2023 - Elsevier
Aims Allergic asthma is associated with anxiety-related behaviors, leading to poor quality of
life. Previous studies mainly described the neuropathophysiology of asthma-induced …

Clinical and experimental aspects of breathing modulation by inflammation

F Peña-Ortega - Autonomic Neuroscience, 2019 - Elsevier
Neuroinflammation is produced by local or systemic alterations and mediated mainly by glia,
affecting the activity of various neural circuits including those involved in breathing rhythm …

The protective effect of inhaled corticosteroid on lung inflammation and breathing pattern complexity in a rat model of asthma

P Enayati, K Dehdar, M Javan, MR Raoufy - Respiratory Physiology & …, 2023 - Elsevier
Asthma is a heterogeneous disease in which the complexity of the breathing pattern reduces
as the severity of the disease increases. Since the pathophysiological basis of reduced …

Mechanopharmacology of Rho-kinase antagonism in airway smooth muscle and potential new therapy for asthma

L Wang, P Chitano, CY Seow - Pharmacological Research, 2020 - Elsevier
The principle of mechanopharmacology of airway smooth muscle (ASM) is based on the
premise that physical agitation, such as pressure oscillation applied to an airway, is able to …

Variable ventilation decreases airway responsiveness and improves ventilation efficiency in a rat model of asthma

F Ilka, M Javan, MR Raoufy - Respiratory physiology & neurobiology, 2018 - Elsevier
The optimal ventilation strategy in patients receiving mechanical ventilation for severe
asthma remains unclear. The effect of conventional ventilation (with constant tidal volume …

Breathing pattern alteration from weanling to old age in male Sprague-Dawley rats

M Eslami-Behroozi, P Shahsavar, R Vali… - Respiratory Physiology & …, 2025 - Elsevier
Respiratory patterns were investigated in male Sprague-Dawley rats throughout their
lifespan, from weanling (1 month) to old age (24 months), under natural conditions. Both …