The gastrointestinal tract has recently come to the forefront of multiple research fields. It is
now recognized as a major source of signals modulating food intake, insulin secretion and …

Excess adipose fat accumulation, or obesity, is a growing problem worldwide in terms of
both the rate of incidence and the severity of obesity-associated metabolic disease. Adipose …

Publisher Summary This chapter discusses the insect CYP genes and P450 enzymes.
Cytochrome P450, or CYP genes, constitutes one of the largest family of genes, with …

Lipid metabolism is fundamental to life. In insects, it is critical, during reproduction, flight,
starvation, and diapause. The coordination center for insect lipid metabolism is the fat body …

Triacylglycerol (TAG) is the most important caloric source with respect to energy
homeostasis in animals. In addition to its evolutionarily conserved importance as an energy …

Metabolism must be coordinated with development to provide the appropriate energetic
needs for each stage in the life cycle. Little is known, however, about how this temporal …

The intestine is a key organ for lipid uptake and distribution, and abnormal intestinal lipid
metabolism is associated with obesity and hyperlipidemia. Although multiple regulatory gut …

Disruptions in energy homeostasis severely affect reproduction in many organisms and are
linked to several reproductive disorders in humans. As a result, understanding the …

Triglycerides are the major form of stored fat in all animals. One important determinant of
whole-body fat storage is whether an animal is male or female. Here, we use Drosophila, an …

Insects, like all eukaryotes, require sterols for structural and metabolic purposes. However,
insects, like all arthropods, cannot make sterols. Cholesterol is the dominant tissue sterol for …