Progress in polymeric micelles for drug delivery applications

S Kotta, HM Aldawsari, SM Badr-Eldin, AB Nair, K Yt - Pharmaceutics, 2022 - mdpi.com
Polymeric micelles (PMs) have made significant progress in drug delivery applications. A
robust core–shell structure, kinetic stability and the inherent ability to solubilize hydrophobic …

Recent advances in developing polymeric micelles for treating cancer: Breakthroughs and bottlenecks in their clinical translation

J Kaur, M Gulati, NK Jha, J Disouza, V Patravale… - Drug Discovery …, 2022 - Elsevier
Polymeric micelles (PMs) have been explored pre-clinically for the delivery of
chemotherapeutics to treat cancer. Their unique features, such as easy surface …

Pluronic F-68 and F-127 based nanomedicines for advancing combination cancer therapy

NU Khaliq, J Lee, S Kim, D Sung, H Kim - Pharmaceutics, 2023 - mdpi.com
Pluronics are amphiphilic triblock copolymers composed of two hydrophilic poly (ethylene
oxide)(PEO) chains linked via a central hydrophobic polypropylene oxide (PPO). Owing to …

Harnessing amphiphilic polymeric micelles for diagnostic and therapeutic applications: Breakthroughs and bottlenecks

J Kaur, V Mishra, SK Singh, M Gulati, B Kapoor… - Journal of Controlled …, 2021 - Elsevier
Amphiphilic block copolymers are widely utilized in the design of formulations owing to their
unique physicochemical properties, flexible structures and functional chemistry. Amphiphilic …

Direct and reverse pluronic micelles: Design and characterization of promising drug delivery nanosystems

A Naharros-Molinero, MÁ Caballo-González… - Pharmaceutics, 2022 - mdpi.com
Pluronics are a family of amphiphilic block copolymers broadly explored in the
pharmaceutical field. Under certain conditions, Pluronics self-assemble in different …

Poloxamers, poloxamines and polymeric micelles: Definition, structure and therapeutic applications in cancer

M Almeida, M Magalhães, F Veiga… - Journal of Polymer …, 2018 - Springer
Research for new therapies to treat diseases like cancer, it is one of the focus of Health
Sciences. Nowadays, the available therapeutic strategies have in many cases limitations …

Advances in designing of polymeric micelles for biomedical application in brain related diseases

J Kaur, M Gulati, B Kapoor, NK Jha, PK Gupta… - Chemico-Biological …, 2022 - Elsevier
In recent years, unique physicochemical properties of amphiphilic block copolymers have
been utilized to design the polymeric micelles for brain-specific delivery of drugs, proteins …

Berberine-loaded thiolated pluronic F127 polymeric micelles for improving skin permeation and retention

J Niu, M Yuan, C Chen, L Wang, Z Tang… - International Journal …, 2020 - Taylor & Francis
Background Challenges associated with local antibacterial and anti-inflammatory drugs
include low penetration and retention of drugs at the expected action site. Additionally …

Drug delivery systems based on Pluronic micelles with antimicrobial activity

C Popovici, M Popa, V Sunel, LI Atanase, DL Ichim - Polymers, 2022 - mdpi.com
Bacterial oral diseases are chronic, and, therefore, require appropriate treatment, which
involves various forms of administration and dosing of the drug. However, multimicrobial …

The synthesis of methotrexate-loaded F127 microemulsions and their in vivo toxicity in a rat model

A Rahdar, MR Hajinezhad, S Nasri, H Beyzaei… - Journal of Molecular …, 2020 - Elsevier
Methotrexate (MTX) has been often formulated as nano and micro-emulsions, nominally to
address its poor solubility and off-target effects. Nanoformulated MTX is universally reported …