Oxidative stress in age-related neurodegenerative diseases: An overview of recent tools and findings

D Korovesis, T Rubio-Tomás, N Tavernarakis - Antioxidants, 2023 - mdpi.com
Reactive oxygen species (ROS) have been described to induce a broad range of redox-
dependent signaling reactions in physiological conditions. Nevertheless, an excessive …

[HTML][HTML] The neuroprotective effects of targeting key factors of neuronal cell death in neurodegenerative diseases: The role of ER stress, oxidative stress, and …

MS Karvandi, F Sheikhzadeh Hesari… - Frontiers in Cellular …, 2023 - frontiersin.org
Neuronal loss is one of the striking causes of various central nervous system disorders,
including major neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's …

Progress in Understanding Oxidative Stress, Aging, and Aging-Related Diseases

J Yang, J Luo, X Tian, Y Zhao, Y Li, X Wu - Antioxidants, 2024 - mdpi.com
Under normal physiological conditions, reactive oxygen species (ROS) are produced
through redox reactions as byproducts of respiratory and metabolic activities. However, due …

Exercise-boosted mitochondrial remodeling in Parkinson's disease

JC Magaña, CM Deus, M Giné-Garriga, J Montané… - Biomedicines, 2022 - mdpi.com
Parkinson's disease (PD) is a movement disorder characterized by the progressive
degeneration of dopaminergic neurons resulting in dopamine deficiency in the striatum …

LPS triggers acute neuroinflammation and parkinsonism involving NLRP3 inflammasome pathway and mitochondrial CI dysfunction in the rat

IE Valenzuela-Arzeta, LO Soto-Rojas… - International Journal of …, 2023 - mdpi.com
Whether neuroinflammation leads to dopaminergic nigrostriatal system neurodegeneration
is controversial. We addressed this issue by inducing acute neuroinflammation in the …

β-carotene-loaded nanoparticles protect against neuromotor damage, oxidative stress, and dopamine deficits in a model of Parkinson's disease in Drosophila …

NSG Chaves, DE Janner, MR Poetini… - … and Physiology Part C …, 2023 - Elsevier
Abstract β-carotene-loaded nanoparticles improves absorption by increasing bioavailability.
The Drosophila melanogaster model of Parkinson's disease must be helpful in investigating …

Effect of systemic inflammation in the CNS: a silent history of neuronal damage

MV Millán Solano, C Salinas Lara… - International Journal of …, 2023 - mdpi.com
Central nervous system (CNS) infections including meningitis and encephalitis, resulting
from the blood-borne spread of specific microorganisms, provoke nervous tissue damage …

The interaction between alpha-synuclein and mitochondrial dysfunction in Parkinson's disease

HY Li, DS Liu, YB Zhang, H Rong, XJ Zhang - Biophysical Chemistry, 2023 - Elsevier
Parkinson's disease (PD) is an aging-associated neurodegenerative disorder with the
hallmark of abnormal aggregates of alpha-synuclein (α-syn) in Lewy bodies (LBs) and Lewy …

VDR and deubiquitination control neuronal oxidative stress and microglial inflammation in Parkinson's disease

Z Zheng, M Chen, S Feng, H Zhao, T Qu, X Zhao… - Cell Death …, 2024 - nature.com
Close correlation between vitamin D (VitD) deficiency and Parkinson's Disease (PD) risk,
VitD as an adjuvant treatment promising to improve PD progression. However, VitD …

Neurodegenerative Diseases: Unraveling the Heterogeneity of Astrocytes

A Santiago-Balmaseda, A Aguirre-Orozco… - Cells, 2024 - mdpi.com
The astrocyte population, around 50% of human brain cells, plays a crucial role in
maintaining the overall health and functionality of the central nervous system (CNS) …