Microtubules play an important role in the process of cell mitosis and can form a spindle in
the mitotic prophase of the cell, which can pull chromosomes to the ends of the cell and then …

The pyrimidine scaffold represents one of the privileged structures in chemistry, and there
has been an increase in number of studies utilizing this scaffold and its derivatives. The …

This study aimed to determine the in vitro cytotoxicity and understand possible cytotoxic
mechanisms via an in silico study of eleven chalcones synthesized from two …

Breast and cervical cancer account for the majority of cancer-narrated fatalities among
women worldwide, necessitating the development of novel, effective therapeutic ways to …

A library of monosubstituted chalcones (1–17) bearing electron-donating and electron-
withdrawing groups on both aromatic rings were selected. The cell viability on human tumor …

Multidrug resistance (MDR) mechanisms in cancer cells are greatly influenced by
glutathione transferase P1-1 (hGSTP1-1). The use of synthetic or natural compounds as …

Abstract We built the Curcumin Chalcone Derivatives Database (CCDD) to enable the
effective virtual screening of highly potent curcumin and its analogs. The two-dimensional …

Abstract The synthesis of novel 5-(2-((1 (E/Z), 2E)-1, 3-disubstitutedallylidene) hydrazinyl)-1,
3-dimethyl-4-nitro-1H-pyrazole (4a–k) was attempted via reaction involves a nucleophilic …

Introduction Cancerremains a leading cause of death worldwide with traditional treatments
likechemotherapy, and radiotherapy becoming less effective due to multidrugresistance …

Without using any solvents, a green and highly efficient protocol for the preparation of
ferrocenyl chalcones has been achieved by grinding between acetylferrocene and …