Targeting PI3K in cancer: mechanisms and advances in clinical trials
Abstract Phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR)
signaling is one of the most important intracellular pathways, which can be considered as a …
signaling is one of the most important intracellular pathways, which can be considered as a …
PI3K inhibitors in cancer: clinical implications and adverse effects
The phospatidylinositol-3 kinase (PI3K) pathway is a crucial intracellular signaling pathway
which is mutated or amplified in a wide variety of cancers including breast, gastric, ovarian …
which is mutated or amplified in a wide variety of cancers including breast, gastric, ovarian …
Lenvatinib plus pembrolizumab for advanced endometrial cancer
Background Standard therapy for advanced endometrial cancer after failure of platinum-
based chemotherapy remains unclear. Methods In this phase 3 trial, we randomly assigned …
based chemotherapy remains unclear. Methods In this phase 3 trial, we randomly assigned …
Targeting the PI3K/AKT/mTOR and RAF/MEK/ERK pathways for cancer therapy
Q Li, Z Li, T Luo, H Shi - Molecular biomedicine, 2022 - Springer
Abstract The PI3K/AKT/mTOR and RAF/MEK/ERK pathways are commonly activated by
mutations and chromosomal translocation in vital targets. The PI3K/AKT/mTOR signaling …
mutations and chromosomal translocation in vital targets. The PI3K/AKT/mTOR signaling …
Targeted therapies in gynecological cancers: A comprehensive review of clinical evidence
Q Wang, H Peng, X Qi, M Wu, X Zhao - Signal Transduction and …, 2020 - nature.com
Advanced and recurrent gynecological cancers are associated with poor prognosis and lack
of effective treatment. The developments of the molecular mechanisms on cancer …
of effective treatment. The developments of the molecular mechanisms on cancer …
Molecular genetics of endometrial carcinoma
DW Bell, LH Ellenson - Annual Review of Pathology …, 2019 - annualreviews.org
Endometrial cancer is the most commonly diagnosed gynecologic malignancy in the United
States. Endometrioid endometrial carcinomas constitute approximately 85% of newly …
States. Endometrioid endometrial carcinomas constitute approximately 85% of newly …
The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis
HV Woodcock, JD Eley, D Guillotin, M Platé… - Nature …, 2019 - nature.com
Myofibroblasts are the key effector cells responsible for excessive extracellular matrix
deposition in multiple fibrotic conditions, including idiopathic pulmonary fibrosis (IPF). The …
deposition in multiple fibrotic conditions, including idiopathic pulmonary fibrosis (IPF). The …
Pathogenic B‐cell receptor signaling in lymphoid malignancies: new insights to improve treatment
Signals emanating from the B‐cell receptor (BCR) promote proliferation and survival in
diverse forms of B‐cell lymphoma. Precision medicine strategies targeting the BCR pathway …
diverse forms of B‐cell lymphoma. Precision medicine strategies targeting the BCR pathway …
Management strategies for recurrent endometrial cancer
EV Connor, PG Rose - Expert Review of Anticancer Therapy, 2018 - Taylor & Francis
Introduction: Endometrial cancer is the most common gynecologic malignancy in the
developed world, and its incidence is increasing. Mortality from this cancer has not improved …
developed world, and its incidence is increasing. Mortality from this cancer has not improved …
Investigational PI3K/AKT/mTOR inhibitors in development for endometrial cancer
F Barra, G Evangelisti, L Ferro Desideri… - Expert opinion on …, 2019 - Taylor & Francis
Introduction: Endometrial cancer (EC) is the most common neoplasm of the female genital
tract in developed countries. Despite the progress in early detection and treatment, a …
tract in developed countries. Despite the progress in early detection and treatment, a …