Translational control of mRNAs is a point of convergence for many oncogenic signals
through which cancer cells tune protein expression in tumorigenesis. Cancer cells rely on …

Malformations of cortical development (MCDs) are neurodevelopmental disorders that result
from abnormal development of the cerebral cortex in utero. MCDs place a substantial …

Epilepsy is a neurological disorder that poses a major threat to public health.
Hyperactivation of mTOR complex 1 (mTORC1) is believed to lead to abnormal network …

The mechanistic target of rapamycin (mTOR) signaling pathway is an essential regulator of
numerous cellular activities such as metabolism, growth, proliferation, and survival. The …

Malformations of cortical development (MCD) are neurological conditions involving focal
disruptions of cortical architecture and cellular organization that arise during …

Hyperactivation of the mechanistic target of rapamycin complex 1 (mTORC1) due to
mutations in genes along the PI3K-mTOR pathway and the GATOR1 complex causes a …

Tuberous sclerosis complex (TSC) is a model disorder for understanding brain development
because the genes that cause TSC are known, many downstream molecular pathways have …

Type II focal cortical dysplasia (FCD) is a neuropathological entity characterised by cortical
dyslamination with the presence of dysmorphic neurons only (FCDIIA) or the presence of …

Objective Low‐level somatic mosaicism in the brain has been shown to be a major genetic
cause of intractable focal epilepsy. However, how a relatively few mutation‐carrying neurons …

Epilepsy is a common neurological disorder affecting over 70 million people worldwide, with
a high rate of pharmaco-resistance, diverse comorbidities including progressive cognitive …