Towards kinetic modeling of genome‐scale metabolic networks without sacrificing stoichiometric, thermodynamic and physiological constraints
Mathematical modeling is an essential tool for the comprehensive understanding of cell
metabolism and its interactions with the environmental and process conditions. Recent …
metabolism and its interactions with the environmental and process conditions. Recent …
Multiscale models of breast cancer progression
Breast cancer initiation, invasion and metastasis span multiple length and time scales.
Molecular events at short length scales lead to an initial tumorigenic population, which left …
Molecular events at short length scales lead to an initial tumorigenic population, which left …
Identification of metabolic engineering targets for the enhancement of 1, 4-butanediol production in recombinant E. coli using large-scale kinetic models
Rational metabolic engineering methods are increasingly employed in designing the
commercially viable processes for the production of chemicals relevant to pharmaceutical …
commercially viable processes for the production of chemicals relevant to pharmaceutical …
A comparative review of computational methods for pathway perturbation analysis: dynamical and topological perspectives
Q Vanhaelen, AM Aliper, A Zhavoronkov - Molecular BioSystems, 2017 - pubs.rsc.org
Stem cells offer great promise within the field of regenerative medicine but despite
encouraging results, the large scale use of stem cells for therapeutic applications still faces …
encouraging results, the large scale use of stem cells for therapeutic applications still faces …
Understanding cancer mechanisms through network dynamics
Cancer is a complex, multifaceted disease. Cellular systems are perturbed both during the
onset and development of cancer, and the behavioural change of tumour cells usually …
onset and development of cancer, and the behavioural change of tumour cells usually …
Insulin signaling in insulin resistance states and cancer: a modeling analysis
Insulin resistance is the common denominator of several diseases including type 2 diabetes
and cancer, and investigating the mechanisms responsible for insulin signaling impairment …
and cancer, and investigating the mechanisms responsible for insulin signaling impairment …
Population heterogeneity in the epithelial to mesenchymal transition is controlled by NFAT and phosphorylated Sp1
R Gould, DM Bassen, A Chakrabarti… - PLoS Computational …, 2016 - journals.plos.org
Epithelial to mesenchymal transition (EMT) is an essential differentiation program during
tissue morphogenesis and remodeling. EMT is induced by soluble transforming growth …
tissue morphogenesis and remodeling. EMT is induced by soluble transforming growth …
Dynamic modeling of cell-free biochemical networks using effective kinetic models
Cell-free systems offer many advantages for the study, manipulation and modeling of
metabolism compared to in vivo processes. Many of the challenges confronting genome …
metabolism compared to in vivo processes. Many of the challenges confronting genome …
Approaches to modeling gene regulatory networks: A gentle introduction
T Schlitt - In Silico Systems Biology, 2013 - Springer
This chapter is split into two main sections; first, I will present an introduction to gene
networks. Second, I will discuss various approaches to gene network modeling which will …
networks. Second, I will discuss various approaches to gene network modeling which will …
Building patient‐specific models for receptor tyrosine kinase signaling networks
K Ebata, S Yamashiro, K Iida, M Okada - The FEBS Journal, 2022 - Wiley Online Library
Cancer progresses due to changes in the dynamic interactions of multidimensional factors
associated with gene mutations. Cancer research has actively adopted computational …
associated with gene mutations. Cancer research has actively adopted computational …