Kinase-targeted cancer therapies: progress, challenges and future directions
KS Bhullar, NO Lagarón, EM McGowan, I Parmar… - Molecular cancer, 2018 - Springer
The human genome encodes 538 protein kinases that transfer a γ-phosphate group from
ATP to serine, threonine, or tyrosine residues. Many of these kinases are associated with …
ATP to serine, threonine, or tyrosine residues. Many of these kinases are associated with …
Ursolic acid—a pentacyclic triterpenoid with a wide spectrum of pharmacological activities
Ł Woźniak, S Skąpska, K Marszałek - Molecules, 2015 - mdpi.com
Ursolic acid (UA) is a natural terpene compound exhibiting many pharmaceutical properties.
In this review the current state of knowledge about the health-promoting properties of this …
In this review the current state of knowledge about the health-promoting properties of this …
[HTML][HTML] The current understanding on the impact of KRAS on colorectal cancer
M Meng, K Zhong, T Jiang, Z Liu, HY Kwan… - Biomedicine & …, 2021 - Elsevier
KRAS (kirsten rat sarcoma viral oncogene) is a member of the RAS family. KRAS mutations
are one of most dominant mutations in colorectal cancer (CRC). The impact of KRAS …
are one of most dominant mutations in colorectal cancer (CRC). The impact of KRAS …
Phenolic compounds in whole grain sorghum and their health benefits
J Xu, W Wang, Y Zhao - Foods, 2021 - mdpi.com
Sorghum grain (Sorghum bicolor L. Moench) is a staple food grown across the globe, and is
mainly cultivated in the semi-arid regions of Africa and Asia. Recently, sorghum grain is …
mainly cultivated in the semi-arid regions of Africa and Asia. Recently, sorghum grain is …
Dietary phytochemicals and their potential effects on obesity: a review
M González-Castejón, A Rodriguez-Casado - Pharmacological research, 2011 - Elsevier
The incidence of obesity is rising at an alarming rate and is becoming a major public health
concern with incalculable social costs. Indeed, obesity facilitates the development of …
concern with incalculable social costs. Indeed, obesity facilitates the development of …
Quercetin: a functional dietary flavonoid with potential chemo‐preventive properties in colorectal cancer
Recently, an intense attention has been paid to the application of natural compounds as a
novel therapeutic strategy for cancer treatment. Quercetin, a natural flavonol present in many …
novel therapeutic strategy for cancer treatment. Quercetin, a natural flavonol present in many …
Antimicrobial activity of oleanolic and ursolic acids: an update
JA Jesus, JHG Lago, MD Laurenti… - Evidence‐Based …, 2015 - Wiley Online Library
Triterpenoids are the most representative group of phytochemicals, as they comprise more
than 20,000 recognized molecules. These compounds are biosynthesized in plants via …
than 20,000 recognized molecules. These compounds are biosynthesized in plants via …
Targets involved in the anti-cancer activity of quercetin in breast, colorectal and liver neoplasms
Phytochemicals have long been effective partners in the fight against several diseases,
including cancer. Among these, flavonoids are valuable allies for both cancer prevention …
including cancer. Among these, flavonoids are valuable allies for both cancer prevention …
Colorectal cancer detection by gold nanoparticle based surface-enhanced Raman spectroscopy of blood serum and statistical analysis
The capabilities of using gold nanoparticle based surface-enhanced Raman spectroscopy
(SERS) to obtain blood serum biochemical information for non-invasive colorectal cancer …
(SERS) to obtain blood serum biochemical information for non-invasive colorectal cancer …
Oleanolic acid and ursolic acid induce apoptosis in four human liver cancer cell lines
S Yan, C Huang, S Wu, M Yin - Toxicology in vitro, 2010 - Elsevier
Apoptotic effects of oleanolic acid (OA) and ursolic acid (UA) on human liver cancer HepG2,
Hep3B, Huh7 and HA22T cell lines were examined. OA or UA at 2, 4, 8μmol/L were used …
Hep3B, Huh7 and HA22T cell lines were examined. OA or UA at 2, 4, 8μmol/L were used …