With research progress on longevity, we have gradually recognized that cardiac aging
causes changes in heart structure and function, including progressive myocardial …

Genetic, environmental, and lifestyle factors primarily determine the lifespan of humans.
From these, nutrition is a key component affecting our health, and several studies …

Recently, there has been an increase in the incidence of malignant tumors among the older
population. Moreover, there is an association between aging and cancer. During the …

Spermidine (SPD) is a natural polyamine present in all living organisms and is involved in
the maintenance of cellular homeostasis by inducing autophagy in different model …

Normal brain aging is accompanied by intensification of free radical processes and
compromised bioenergetics. Caloric restriction is expected to counteract these changes but …

Aging-induced neurodegenerative diseases (NDs) are significantly increasing health
problem worldwide. It has been well documented that oxidative stress is one of the potential …

Circadian rhythms (CRs) are intrinsic clocks organizing the behavior and physiology of
organisms. These clocks are thought to have coevolved with cellular redox regulation …

Elderly population and age-related diseases are on the rise. On the contrary, aging studies
are technically hard to conduct, because they require elderly animals, the maintenance of …

Significance: It is well established that lifestyle and dietary habits have a tremendous impact
on life span, the rate of aging, and the onset/progression of age-related diseases …

Despite recent studies have shown that caloric restriction (CR) could improve some
functional loss associated with brain aging, the biochemical effects of CR on brain aging are …