A great deal of experimental evidence suggests that ligands can stabilize different receptor
active states that go on to interact with cellular signaling proteins to form a range of different …

A significant challenge for neuroscientists is to determine how both electrical and chemical
signals affect the activity of cells and circuits and how the nervous system subsequently …

Examining the behavioral consequences of selective CNS neuronal activation is a powerful
tool for elucidating mammalian brain function in health and disease. Newly developed …

We are creating families of designer G protein–coupled receptors (GPCRs) to allow for
precise spatiotemporal control of GPCR signaling in vivo. These engineered GPCRs, called …

Rosiglitazone (Rosi), a member of the thiazolidinedione class of drugs used to treat type 2
diabetes, activates the adipocyte‐specific transcription factor peroxisome proliferator …

A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery, Fifth
Edition features the latest ideas and research regarding the application of pharmacology to …

Highlights•DREADD is the acronym for Designer Receptors Exclusively Activated by
Designer Drugs.•Available DREADDs are activated by the inert ligand clozapine-N …

As the vertebrate skeleton develops it progresses from a solely cartilaginous scaffold to a
mineralized bony skeleton. The cells that build up the skeleton, the chondrocytes and …

Osteoblasts are essential for maintaining bone mass, avoiding osteoporosis, and repairing
injured bone. Activation of osteoblast G protein-coupled receptors (GPCRs), such as the …

The chemokine CXCL12 and its receptor CXCR4 play a key role in regulation of
hematopoietic stem cells and cell migratory function during morphogenesis. Osteoblasts …