Neutrophils or polymorphonuclear leukocytes (PMN) are key participants in the innate
immune response for their ability to execute different effector functions. These cells express …

Neutrophils, the most abundant human immune cells, are rapidly recruited to sites of
infection, where they fulfill their life-saving antimicrobial functions. While traditionally …

Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic
acid-responsive gene during embryogenesis, but currently viewed as a multifaceted factor …

Present review article highlights various cardiovascular risk prediction biomarkers by
incorporating both traditional risk factors to be used as diagnostic markers and recent …

An open question in aggressive cancers such as melanoma is how malignant cells can shift
the immune system to pro-tumorigenic functions. Here we identify midkine (MDK) as a …

Rheumatoid arthritis (RA) involves several classes of pathogenic autoantibodies, some of
which react with type-II collagen (COL2) in articular cartilage. We previously described a …

Heart failure due to dilated cardiomyopathy is frequently caused by myocarditis. However,
the pathogenesis of myocarditis remains incompletely understood. Here, we report the …

Heart failure threatens the lives of patients and reduces their quality of life. Heart failure,
especially heart failure with preserved ejection fraction, is closely related to systemic and …

Sorafenib, a multiple-target tyrosine kinase inhibitor, is the standard of care for patients with
advanced hepatocellular carcinoma (HCC), but provides limited benefits. Emerging …

Midkine (MK) is a heparin-binding growth factor that promotes carcinogenesis and
chemoresistance. The tumour microenvironment (TME) can affect chemotherapy sensitivity …