Over the past 30 yr, there have been marked improvements in the opioids available to
clinicians. The major emphasis in the development of opioids has been increasing potency …

Aneurysmal subarachnoid hemorrhage is an acute neurologic emergency. Prompt definitive
treatment of the aneurysm by craniotomy and clipping or endovascular intervention with …

Introduction This randomised, open-label, observational, multicentre, parallel group study
assessed the safety and efficacy of analgesia-based sedation using remifentanil in the …

Background Remifentanil hydrochloride is an ultra-short-acting, esterase-metabolized mu-
opioid receptor agonist. This study compared the use of remifentanil or fentanyl during …

The aim of this study was to compare the analgesic efficacy of three different postoperative
treatments after supratentorial craniotomy. Sixty-four patients were allocated prospectively …

Purpose: To elucidate mechanisms by which remifentanil, an ultra-short-acting μ-opioid
receptor agonsit, causes hypotension and bradycardia. Methods: Mean arterial pressure …

Background The current study investigates the effects of morphine and fentanyl upon
intracranial pressure and cerebral blood flow estimated by cerebral arteriovenous oxygen …

Remifentanil is still in its infancy in terms of postmarketing development. Its appropriate role
in modern anesthesia care is still being defined and reports of novel clinical applications for …

Background The purpose of this randomised, single-centre study was to prospectively
investigate the impact of anaesthetic techniques for craniotomy on the release of cytokines …

Background and aim: Remifentanil is an ultra‐short‐acting opioid, increasingly used today
in neuroanesthesia and neurointensive care. Its characteristics make remifentanil a …