Background Grip strength, walking speed, chair rising and standing balance time are
objective measures of physical capability that characterise current health and predict …

Background Exposure to early-life adversity is known to predict DNA methylation (DNAm)
patterns that may be related to psychiatric risk. However, few studies have investigated …

Frailty is an important consequence of ageing, whereby frail patients are more likely to face
adverse outcomes, such as disability and death. Risk of frailty increases in people with poor …

Background Early maternal age at first birth and elevated parity may have long-term
consequences for the health of women as they age. Both are known risk factors for …

The persistently high prevalence of girl-child marriage and adolescent motherhood is a
public health concern in Bangladesh. This study investigated the division-wise prevalence …

Life course epidemiology emerged in the 1990s as a response to the growing rift between
differing theoretical models of disease etiology. As such it attempted to synthesize existing …

Epidemiologists are often interested in examining the effect on a later-life outcome of an
exposure measured repeatedly over the life course. When different hypotheses for this effect …

Objective: The reserve hypothesis accounts for the lack of direct relationship between brain
pathology and its clinical manifestations. Research has mostly focused on cognition; our …

The relative contribution of early or later life Socio Economic Position (SEP) to later life
health is not fully understood and there are alternative hypotheses about the pathways …

Background Different hypotheses have been proposed in life course epidemiology on how a
time-varying exposure can affect health or disease later in life. Researchers are often …