In the past 8 years, there has been renewed interest in the role of iron in both acute kidney
injury (AKI) and chronic kidney disease (CKD). In patients with kidney diseases, renal …

In humans, β‐thalassemia dyserythropoiesis is characterized by expansion of early erythroid
precursors and erythroid progenitors and then ineffective erythropoiesis. This ineffective …

This aim of this statement is to report an expert consensus on the diagnosis and treatment of
cardiac dysfunction in β-thalassemia major (TM). This consensus statement does not cover …

BACKGROUND AND OBJECTIVES: Iron accumulation is an inevitable consequence of
chronic blood transfusions and results in serious complications in the absence of chelation …

Background: In beta-thalassemia major impaired biosynthesis of beta globin leads to
accumulation of unpaired alpha globin chain. An iron overload, usually observed, generates …

Little is known about the effects of thalassaemia on the kidney. Characterization of
underlying renal function abnormalities in thalassaemia is timely because the newer iron …

Thalassemia is among the most common monogenic diseases worldwide. Stem cell
transplantation can be curative but is reserved for young patients, as probably gene therapy …

Increased survival in patients with β thalassaemia major (TM) allowed for several morbidities
to manifest. Renal manifestations of the disease and its treatment have been poorly …

Background In β-thalassemia, profound anemia and severe hemosiderosis cause functional
and physiological abnormalities in various organ systems. In recent years, there have been …

Purpose To study the pattern, etiology, and significance of renal iron accumulation in
chronically transfused sickle cell disease (SCD) and thalassemia major (TM) patients using …