Chromone as a privileged scaffold in drug discovery: recent advances: miniperspective

J Reis, A Gaspar, N Milhazes… - Journal of medicinal …, 2017 - ACS Publications
The use of privileged structures in drug discovery has proven to be an effective strategy,
allowing the generation of innovative hits/leads and successful optimization processes …

Current strategies in development of new chromone derivatives with diversified pharmacological activities: A review

NA Mohsin, M Irfan, S Hassan, U Saleem - Pharmaceutical chemistry …, 2020 - Springer
Chromone derivatives possess a spectrum of biological activities. Chromone has been
recognized as a privileged structure for new drug invention and development. Substitution …

Palladium-mediated C–O bond activation of benzopyrone in 4-oxo-4 H-chromone-3-carbaldehyde-4 (N)-substituted thiosemicarbazone: synthesis, structure, nucleic …

A Shanmugapriya, G Kalaiarasi, M Ravi… - New Journal of …, 2021 - pubs.rsc.org
Palladium ion-mediated C–O activation at the C2 carbon of the benzopyrone moiety of 3-
formylchromone-4 (N)-substituted thiosemicarbazone (HL1–4) has been observed in square …

Synthesis and evaluation of chromene-based compounds containing pyrazole moiety as antimicrobial agents

MSK Youssef, AAO Abeed, TI El-Emary - Heterocyclic …, 2017 - degruyter.com
With an intention to synergize the antimicrobial activity of 1, 3-diphenyl pyrazole and
chromene derivatives, 20 hybrid compounds were synthesized and evaluated for their …

Chitosan nanoparticles of new chromone-based sulfonamide derivatives as effective anti-microbial matrix for wound healing acceleration

HM Abo-Salem, EAB Ali, H Abdelmegeed… - International Journal of …, 2024 - Elsevier
A new series of chromone and furochromone-based sulfonamide Schiff's base derivatives 3–
12 were synthesized and evaluated for their antimicrobial activity against S. aureus, E. coli …

Specific solvent effect on the photophysical behavior of substituted chromones: A combined fluorescence, DFT and MD study

MA Rohman, P Baruah, SO Yesylevskyy, S Mitra - Chemical Physics, 2019 - Elsevier
Solvent dependent photophysical properties of two chromone derivatives, namely 7-amino-2-
methyl chromone (AMC) and 3-cyano chromone (CyC), were studied by time-resolved …

Reactions of 3-functionalized chromones with triacetic acid lactone

MY Kornev, DS Tishin, DL Obydennov… - Mendeleev …, 2020 - Elsevier
Reaction of 3-formylchromones and triacetic acid lactone proceeds with retention of the
chromone skeleton and cyclization into pyrano [3′, 4′: 5, 6] pyrano [2, 3-b] chromene …

Synthesis and cytotoxicity evaluation of some novel chromone annulated phosphorus heterocycles

TE Ali, MA Ibrahim, SM El-Edfawy - Phosphorus, Sulfur, and …, 2017 - Taylor & Francis
ABSTRACT Novel chromono [2, 3-e][1, 2, 4, 3] triazaphosphepines 3− 7, chromono [2, 3-
d][1, 3, 2] diazaphosphinine 8, chro-monyl α-hydrazinophosphonic acid 10, chromono [3, 2 …

ZnO nanoparticles as a highly efficient heterogeneous catalyst for the synthesis of various chromene and pyrano[4,3-b]pyran derivatives under solvent-free conditions

Z Hossaini, F Sheikholeslami-Farahani… - Chemistry of …, 2015 - Springer
Three-component reaction of 4-hydroxy-2 H-pyran-2-one, aldehydes, and malononitrile or
ethyl cyanoacetate in the presence of ZnO nanoparticles as the catalyst is described as an …

Nucleophilic reactions with 3-formylchromones: A decade update

MA Ibrahim, M Abdel-Megid, O Farouk… - Synthetic …, 2024 - Taylor & Francis
The chemical reactivity of 3-formylchromones toward several carbon and nitrogen
nucleophiles is collected in this review. Certain annulated chromones and 3-heteroaryl …