The site-selective modification of peptide backbones allows an outstanding fine-tuning of
peptide conformation, folding ability, and physico-chemical and biological properties …

Numerous strategies for linking desired chemical probes with target peptides and proteins
have been developed and applied in the field of biological chemistry. Approaches for site …

Sortases are enzymes occurring in the cell wall of Gram-positive bacteria. Sortase A (SrtA),
the best studied sortase class, plays a key role in anchoring surface proteins with the …

Comprehensive Summary Protein glycosylation is the most complex and diverse form of
post‐translational modification in human body. Meanwhile, glycosylation of peptides and …

Covalent attachment of therapeutic proteins to polyethylene glycol (PEG) is widely used for
the improvement of its pharmacokinetic and pharmacological properties, as well as the …

The fabrication of novel biomaterial scaffolds with improved biological interactions and
mechanical properties is an important aspect of tissue engineering. The three-dimensional …

Asparaginyl ligases have been extensively utilized as valuable tools for site-specific
bioconjugation or surface-modification. However, the application is hindered by the …

A rational design approach is proposed for a multifunctional enzyme reagent for point-of-
care diagnostics. The biomaterial reduces downstream isolation steps and eliminates …

Numerous enzymes of biotechnological importance have been immobilized on magnetic
nanoparticles (MNP) via random multipoint attachment, resulting in a heterogeneous protein …

Chemical modification of native peptides and proteins is a versatile strategy to facilitate late-
stage diversification for functional studies. Among the proteogenic amino acids, lysine is …