Serotonin is perhaps best known as a neurotransmitter that modulates neural activity and a
wide range of neuropsychological processes, and drugs that target serotonin receptors are …

Serotonin (5-hydroxytryptamine, 5-HT) plays two important roles in humans—one central
and the other peripheral—depending on the location of the 5-HT pools of on either side of …

Adverse outcome pathways (AOPs) organize knowledge on the progression of toxicity
through levels of biological organization. By determining the linkages between toxicity …

Because life is often unpredictable, dynamic, and complex, all animals have evolved
remarkable abilities to cope with changes in their external environment and internal …

Over the past 20 years, genetic studies have illuminated critical pathways in the
hypothalamus and brainstem mediating energy homeostasis, such as the melanocortin …

Background Although obesity and cardiometabolic traits commonly overlap, underlying
pathways remain incompletely defined. The association of metabolite profiles across …

Energy and glucose homeostasis are regulated by central serotonin 2C receptors. These
receptors are attractive pharmacological targets for the treatment of obesity; however, the …

Liver glycogen is synthesized after a meal in response to an increase in blood glucose
concentration in the portal vein and endocrine and neuroendocrine signals, and is degraded …

The neurotransmitter serotonin (5-hydroxytryptamine) is a well-established modulator of
energy balance. Both pharmacological and genetic evidence implicate the serotonin 2C …

Obesity is associated with several diseases, including mental health. Adipose tissue is
distributed around the internal organs, acting in the regulation of metabolism by storing and …