The Mycobacterium tuberculosis complex (MTBC) consists of closely related species that
cause tuberculosis in both humans and animals. This illness, still today, remains to be one of …

Tuberculosis (TB), one of the oldest known human diseases. is still is one of the major
causes of mortality, since two million people die each year from this malady. TB has many …

We have taken the first steps towards a complete reconstruction of the Mycobacterium
tuberculosis regulatory network based on ChIP-Seq and combined this reconstruction with …

Actinobacteria constitute one of the largest phyla among Bacteria and represent gram-
positive bacteria with a high G+ C content in their DNA. This bacterial group includes …

The search for new TB drugs that rapidly and effectively sterilize the tissues and are thus
able to shorten the duration of chemotherapy from the current 6 months has been hampered …

Despite the importance of tuberculosis as a public health problem, we know relatively little
about the molecular mechanisms used by the causative organism, Mycobacterium …

Little is known about the biochemical environment in phagosomes harboring an infectious
agent. To assess the state of this organelle we captured the transcriptional responses of …

This review summarizes recent evidence from knock-out mice on the role of reactive oxygen
intermediates and reactive nitrogen intermediates (RNI) in mammalian immunity. Reflections …

Leprosy, a chronic human neurological disease, results from infection with the obligate
intracellular pathogen Mycobacterium leprae, a close relative of the tubercle bacillus …

Although phthiocerol dimycocerosates (DIM) are major virulence factors of Mycobacterium
tuberculosis (Mtb), the causative agent of human tuberculosis, little is known about their …