The assembly of ribosomal subunits is a highly orchestrated process that involves a huge
cohort of accessory factors. Most eukaryotic ribosome biogenesis factors were first identified …

In the past 25 years, genetic and biochemical analyses of ribosome assembly in yeast have
identified most of the factors that participate in this complex pathway and have generated …

Ribosomes, which synthesize the proteins of a cell, comprise ribosomal RNA and ribosomal
proteins, which coassemble hierarchically during a process termed ribosome biogenesis …

INTRODUCTION The ribosome catalyzes protein synthesis in all cells by coupling the
decoding of messenger RNA by the small ribosomal subunit with peptide bond formation by …

The essential cellular process of ribosome biogenesis is at the nexus of various signalling
pathways that coordinate protein synthesis with cellular growth and proliferation. The fact …

The biogenesis of eukaryotic ribosomes is a complicated process during which the
transcription, modification, folding, and processing of the rRNA is coupled with the ordered …

Production of small ribosomal subunits initially requires the formation of a 90 S precursor
followed by an enigmatic process of restructuring into the primordial pre-40 S subunit. We …

Abstract The transcription of 18S, 5.8 S, and 18S rRNA genes (45S rDNA), cotranscriptional
processing of pre-rRNA, and assembly of mature rRNA with ribosomal proteins are the …

Eukaryotic small ribosomal subunits are first assembled into 90S pre-ribosomes. The
complete 90S is a gigantic complex with a molecular mass of approximately five …

The coordinated integration of ribosomal RNA and protein into two functional ribosomal
subunits is safeguarded by quality control checkpoints that ensure ribosomes are correctly …