NAD+ metabolism and its roles in cellular processes during ageing
Nicotinamide adenine dinucleotide (NAD+) is a coenzyme for redox reactions, making it
central to energy metabolism. NAD+ is also an essential cofactor for non-redox NAD+ …
central to energy metabolism. NAD+ is also an essential cofactor for non-redox NAD+ …
NAD+ homeostasis in health and disease
The conceptual evolution of nicotinamide adenine dinucleotide (NAD+) from being seen as
a simple metabolic cofactor to a pivotal cosubstrate for proteins regulating metabolism and …
a simple metabolic cofactor to a pivotal cosubstrate for proteins regulating metabolism and …
[HTML][HTML] Saturation of the mitochondrial NADH shuttles drives aerobic glycolysis in proliferating cells
Proliferating cells exhibit a metabolic phenotype known as" aerobic glycolysis," which is
characterized by an elevated rate of glucose fermentation to lactate irrespective of oxygen …
characterized by an elevated rate of glucose fermentation to lactate irrespective of oxygen …
Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages
Declining tissue nicotinamide adenine dinucleotide (NAD) levels are linked to ageing and its
associated diseases. However, the mechanism for this decline is unclear. Here, we show …
associated diseases. However, the mechanism for this decline is unclear. Here, we show …
Regulation of and challenges in targeting NAD+ metabolism
Nicotinamide adenine dinucleotide, in its oxidized (NAD+) and reduced (NADH) forms, is a
reduction–oxidation (redox) co-factor and substrate for signalling enzymes that have …
reduction–oxidation (redox) co-factor and substrate for signalling enzymes that have …
CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels
CCS Chini, TR Peclat, GM Warner, S Kashyap… - Nature …, 2020 - nature.com
Decreased NAD+ levels have been shown to contribute to metabolic dysfunction during
aging. NAD+ decline can be partially prevented by knockout of the enzyme CD38. However …
aging. NAD+ decline can be partially prevented by knockout of the enzyme CD38. However …
Lactate limits T cell proliferation via the NAD (H) redox state
WJ Quinn, J Jiao, T TeSlaa, J Stadanlick, Z Wang… - Cell reports, 2020 - cell.com
Immune cell function is influenced by metabolic conditions. Low-glucose, high-lactate
environments, such as the placenta, gastrointestinal tract, and the tumor microenvironment …
environments, such as the placenta, gastrointestinal tract, and the tumor microenvironment …
[HTML][HTML] Evolving concepts in NAD+ metabolism
CCS Chini, JD Zeidler, S Kashyap, G Warner, EN Chini - Cell metabolism, 2021 - cell.com
Summary NAD (H) and NADP (H) have traditionally been viewed as co-factors (or co-
enzymes) involved in a myriad of oxidation-reduction reactions including the electron …
enzymes) involved in a myriad of oxidation-reduction reactions including the electron …
[HTML][HTML] Nicotinamide riboside augments the aged human skeletal muscle NAD+ metabolome and induces transcriptomic and anti-inflammatory signatures
YS Elhassan, K Kluckova, RS Fletcher, MS Schmidt… - Cell reports, 2019 - cell.com
Nicotinamide adenine dinucleotide (NAD+) is modulated by conditions of metabolic stress
and has been reported to decline with aging in preclinical models, but human data are …
and has been reported to decline with aging in preclinical models, but human data are …
NAD+ Metabolism in Cardiac Health, Aging, and Disease
Nicotinamide adenine dinucleotide (NAD+) is a central metabolite involved in energy and
redox homeostasis as well as in DNA repair and protein deacetylation reactions …
redox homeostasis as well as in DNA repair and protein deacetylation reactions …