Human KIR repertoires: shaped by genetic diversity and evolution

AR Manser, S Weinhold, M Uhrberg - Immunological reviews, 2015 - Wiley Online Library
Killer cell immunoglobulin‐like receptors (KIR s) on natural killer (NK) cells are crucially
involved in the control of cancer development and virus infection by probing cells for proper …

Activating killer cell immunoglobulin‐like receptors: detection, function and therapeutic use

MD Blunt, SI Khakoo - International Journal of Immunogenetics, 2020 - Wiley Online Library
Killer cell immunoglobulin‐like receptors (KIRs) have a central role in the control of natural
killer (NK) cell function. The functions of the activating KIRs, as compared to those of the …

A KIR B centromeric region present in Africans but not Europeans protects pregnant women from pre-eclampsia

A Nakimuli, O Chazara, SE Hiby… - Proceedings of the …, 2015 - National Acad Sciences
In sub-Saharan Africans, maternal mortality is unacceptably high, with> 400 deaths per
100,000 births compared with< 10 deaths per 100,000 births in Europeans. One-third of the …

Deciphering the killer‐cell immunoglobulin‐like receptor system at super‐resolution for natural killer and T‐cell biology

V Béziat, HG Hilton, PJ Norman, JA Traherne - Immunology, 2017 - Wiley Online Library
Killer‐cell immunoglobulin‐like receptors (KIR s) are components of two fundamental
biological systems essential for human health and survival. First, they contribute to host …

NK cell dysfunction in chronic lymphocytic leukemia is associated with loss of the mature cells expressing inhibitory killer cell Ig-like receptors

AW MacFarlane IV, M Jillab, MR Smith… - …, 2017 - Taylor & Francis
ABSTRACT A prospective analysis of natural killer (NK) cell phenotype and function was
performed on fresh peripheral blood samples from untreated patients with B-cell chronic …

Activating killer cell Ig-like receptors in health and disease

MA Ivarsson, J Michaëlsson, C Fauriat - Frontiers in immunology, 2014 - frontiersin.org
Expression of non-rearranged HLA class I-binding receptors characterizes human and
mouse NK cells. The postulation of the missing-self hypothesis some 30 years ago triggered …

Glioblastoma stem-like cells are more susceptible than differentiated cells to natural killer cell lysis mediated through killer immunoglobulin-like receptors–human …

HN Haspels, MA Rahman, JV Joseph… - Frontiers in …, 2018 - frontiersin.org
Glioblastoma (GBM) is the most aggressive brain malignancy in adults, where survival is
approximately 14.6 months. Novel therapies are urgently needed and immunotherapy has …

Activating KIRs and NKG2C in viral infections: toward NK cell memory?

M Della Chiesa, S Sivori, S Carlomagno… - Frontiers in …, 2015 - frontiersin.org
Natural killer (NK) cells are important players in the immune defense against viral infections.
The contribution of activating killer immunoglobulin-like receptors (KIRs) and CD94/NKG2C …

Natural killer cell education is associated with a distinct glycolytic profile

C Pfeifer, AJ Highton, S Peine, J Sauter… - Frontiers in …, 2018 - frontiersin.org
NK cells expressing self-inhibitory receptors display increased functionality compared to NK
cells lacking those receptors. The acquisition of functional competence in these particular …

A CD8+ NK cell transcriptomic signature associated with clinical outcome in relapsing remitting multiple sclerosis

EF McKinney, I Cuthbertson, KM Harris… - Nature …, 2021 - nature.com
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system (CNS) with the majority of cases characterised by relapsing/remitting (RRMS) attacks …