MD Blunt, SI Khakoo - International Journal of Immunogenetics, 2020 - Wiley Online Library
Killer cell immunoglobulin‐like receptors (KIRs) have a central role in the control of natural killer (NK) cell function. The functions of the activating KIRs, as compared to those of the …
A Nakimuli, O Chazara, SE Hiby… - Proceedings of the …, 2015 - National Acad Sciences
In sub-Saharan Africans, maternal mortality is unacceptably high, with> 400 deaths per 100,000 births compared with< 10 deaths per 100,000 births in Europeans. One-third of the …
Killer‐cell immunoglobulin‐like receptors (KIR s) are components of two fundamental biological systems essential for human health and survival. First, they contribute to host …
ABSTRACT A prospective analysis of natural killer (NK) cell phenotype and function was performed on fresh peripheral blood samples from untreated patients with B-cell chronic …
Expression of non-rearranged HLA class I-binding receptors characterizes human and mouse NK cells. The postulation of the missing-self hypothesis some 30 years ago triggered …
HN Haspels, MA Rahman, JV Joseph… - Frontiers in …, 2018 - frontiersin.org
Glioblastoma (GBM) is the most aggressive brain malignancy in adults, where survival is approximately 14.6 months. Novel therapies are urgently needed and immunotherapy has …
Natural killer (NK) cells are important players in the immune defense against viral infections. The contribution of activating killer immunoglobulin-like receptors (KIRs) and CD94/NKG2C …
C Pfeifer, AJ Highton, S Peine, J Sauter… - Frontiers in …, 2018 - frontiersin.org
NK cells expressing self-inhibitory receptors display increased functionality compared to NK cells lacking those receptors. The acquisition of functional competence in these particular …
EF McKinney, I Cuthbertson, KM Harris… - Nature …, 2021 - nature.com
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) with the majority of cases characterised by relapsing/remitting (RRMS) attacks …