Despite great advances in the development of modern anticancer drugs, it is still challenging
to find safer and more effective ones due to a new spectrum of diseases and emerging drug …

PIM kinases are oncogenic serine/threonine kinases, the expression and activities of which
are tightly regulated in normal tissues, but upregulated in many types of human …

Radioresistance is a major cause of decreasing the efficiency of radiotherapy for non-small
cell lung cancer (NSCLC). To understand the radioresistance mechanisms in NSCLC, we …

Acquired resistance is inevitable in the treatment of non-small cell lung cancer (NSCLC) with
osimertinib, and one of the primary mechanisms responsible for this resistance is the …

Abstract Background Proviral integration Moloney virus (PIM) kinases (PIM1, 2 and 3) are
overexpressed in several tumour types and contribute to oncogenesis. AZD1208 is a potent …

The family of PIM serine/threonine kinases includes three highly conserved oncogenes,
PIM1, PIM2, and PIM3, which regulate multiple prosurvival pathways and cooperate with …

Abstract The p21-activated Ser/Thr kinase 1 (PAK1) kinase has an essential role in
tumorigenesis and cell survival in many cancers, but its regulation is not fully understood. In …

TFAP2C (transcription factor-activating enhancer-binding protein 2C) expression has been
positively correlated with poor prognosis in patients with certain types of cancer, but the …

The PIM 1 protein is an important regulator of cell proliferation, the cell cycle, apoptosis, and
metabolism in various human cancers. Micro RNA s (mi RNA s) are powerful post …

Glioblastomas (GBM) is the most common primary malignant brain tumor, and radiotherapy
plays a critical role in its therapeutic management. Unfortunately, the development of …