Bioavailability enhancement techniques for poorly aqueous soluble drugs and therapeutics

DV Bhalani, B Nutan, A Kumar, AK Singh Chandel - Biomedicines, 2022 - mdpi.com
The low water solubility of pharmacoactive molecules limits their pharmacological potential,
but the solubility parameter cannot compromise, and so different approaches are employed …

Cyclodextrins: Structural, chemical, and physical properties, and applications

BG Poulson, QA Alsulami, A Sharfalddin… - Polysaccharides, 2021 - mdpi.com
Due to their unique structural, physical and chemical properties, cyclodextrins and their
derivatives have been of great interest to scientists and researchers in both academia and …

Cyclodextrin metal–organic frameworks and derivatives: recent developments and applications

SV Dummert, H Saini, MZ Hussain, K Yadava… - Chemical Society …, 2022 - pubs.rsc.org
While there is a tremendous amount of scientific research on metal organic frameworks
(MOFs) for gas storage/separation, catalysis and energy storage, the development and …

Research status of self-healing hydrogel for wound management: A review

A Zhang, Y Liu, D Qin, M Sun, T Wang… - International Journal of …, 2020 - Elsevier
Wound management has attracted significant interest in view of the broad demand market.
Dressings are playing crucial roles in wounds management because they can protect the …

Drug delivery by supramolecular design

MJ Webber, R Langer - Chemical Society Reviews, 2017 - pubs.rsc.org
The rational design of drug delivery approaches leveraging supramolecular chemistry
(ie,“chemistry beyond the molecule”) has garnered significant interest in recent years toward …

Cyclodextrin–drug inclusion complexes: In vivo and in vitro approaches

SB Carneiro, FI Costa Duarte, L Heimfarth… - International journal of …, 2019 - mdpi.com
This review aims to provide a critical review of the biological performance of natural and
synthetic substances complexed with cyclodextrins, highlighting:(i) inclusion complexes with …

Biopolymer nano-particles and natural nano-carriers for nano-encapsulation of phenolic compounds

AF Esfanjani, SM Jafari - Colloids and Surfaces B: Biointerfaces, 2016 - Elsevier
Phenolic compounds are major micronutrients in our diet, 1 and evidence for their role in the
prevention of degenerative diseases such as cancer, inflammation and neurodegenerative …

[HTML][HTML] Biomedical applications of supramolecular systems based on host–guest interactions

X Ma, Y Zhao - Chemical reviews, 2015 - ACS Publications
The development of supramolecular chemistry dates back to 1987 when Lehn, Cram, and
Pedersen won the Nobel Prize on account of their leading discoveries in the host–guest …

Cyclodextrin-based ocular drug delivery systems: A comprehensive review

Q Wang, A Zhang, L Zhu, X Yang, G Fang… - Coordination Chemistry …, 2023 - Elsevier
Cyclodextrin (CD), a class of cyclic oligosaccharides with an external hydrophilic surface
and a central hydrophobic cavity is recognized as a promising pharmaceutical excipient due …

Polymorph impact on the bioavailability and stability of poorly soluble drugs

R Censi, P Di Martino - Molecules, 2015 - mdpi.com
Drugs with low water solubility are predisposed to poor and variable oral bioavailability and,
therefore, to variability in clinical response, that might be overcome through an appropriate …