Cytokine dysregulation in autism spectrum disorders (ASD): possible role of the environment

PE Goines, P Ashwood - Neurotoxicology and teratology, 2013 - Elsevier
Autism spectrum disorders (ASD) are neurodevelopmental diseases that affect an alarming
number of individuals. The etiological basis of ASD is unclear, and evidence suggests it …

Cyclic nucleotide compartmentalization: contributions of phosphodiesterases and ATP-binding cassette transporters

S Cheepala, JS Hulot, JA Morgan… - Annual review of …, 2013 - annualreviews.org
Cyclic nucleotides [eg, cyclic adenosine monophosphate (cAMP) and cyclic guanosine
monophosphate (cGMP)] are ubiquitous second messengers that affect multiple cell …

Differentiation of neural stem cells in three-dimensional growth factor-immobilized chitosan hydrogel scaffolds

ND Leipzig, RG Wylie, H Kim, MS Shoichet - Biomaterials, 2011 - Elsevier
The adult central nervous system (CNS) contains adult neural stem/progenitor cells (NSPCs)
that possess the ability to differentiate into the primary cell types found in the CNS and to …

Intrathecal delivery of a polymeric nanocomposite hydrogel after spinal cord injury

MD Baumann, CE Kang, CH Tator, MS Shoichet - Biomaterials, 2010 - Elsevier
Major traumatic spinal cord injury (SCI) results in permanent paralysis below the site of
injury. The effectiveness of systemically delivered pharmacological therapies against SCI …

Neural stem/progenitor cells from the adult human spinal cord are multipotent and self-renewing and differentiate after transplantation

AJ Mothe, T Zahir, C Santaguida, D Cook, CH Tator - PloS one, 2011 - journals.plos.org
Neural stem/progenitor cell (NSPC) transplantation is a promising therapy for spinal cord
injury (SCI). However, little is known about NSPC from the adult human spinal cord as a …

Multifaceted roles of cAMP signaling in the repair process of spinal cord injury and related combination treatments

G Zhou, Z Wang, S Han, X Chen, Z Li, X Hu… - Frontiers in Molecular …, 2022 - frontiersin.org
Spinal cord injury (SCI) results in multiple pathophysiological processes, including blood–
spinal cord barrier disruption, hemorrhage/ischemia, oxidative stress, neuroinflammation …

Effects of dibutyryl cyclic-AMP on survival and neuronal differentiation of neural stem/progenitor cells transplanted into spinal cord injured rats

H Kim, T Zahir, CH Tator, MS Shoichet - PloS one, 2011 - journals.plos.org
Neural stem/progenitor cells (NSPCs) have great potential as a cell replacement therapy for
spinal cord injury. However, poor control over transplant cell differentiation and survival …

Hydrogel/electrospun fiber composites influence neural stem/progenitor cell fate

A Hsieh, T Zahir, Y Lapitsky, B Amsden, W Wan… - Soft Matter, 2010 - pubs.rsc.org
Cell replacement therapy with multi-potent neural stem/progenitor cells (NSPCs) into the
injured spinal cord is limited by poor survival and host tissue integration. An injectable and …

Functional immobilization of interferon‐gamma induces neuronal differentiation of neural stem cells

ND Leipzig, C Xu, T Zahir… - Journal of Biomedical …, 2010 - Wiley Online Library
Stem cell transplantation provides significant promise to regenerative strategies after injury
in the central nervous system. Neural stem/progenitor cells (NSPCs) have been studied in …

Influence of oriented nanofibrous PCL scaffolds on quantitative gene expression during neural differentiation of mouse embryonic stem cells

N Abbasi, SM Hashemi, M Salehi… - … Research Part A, 2016 - Wiley Online Library
Neural differentiation of mouse embryonic stem cells in combination with three‐dimensional
electrospun nanofibers as an artificial extracellular matrix can be utilized to reconstruct a …