Rho family small GTPases serve as molecular switches involved in the regulation of diverse
cellular functions including various cytoskeleton-related events and gene transcription. The …

Typical members of the Ras superfamily of small monomeric GTP-binding proteins function
as regulators of diverse processes by cycling between biologically active GTP-and inactive …

In recent years small G proteins have become an intensively studied group of regulatory
GTP hydrolases involved in cell signaling. More than 100 small G proteins have been …

Proteins containing a RhoGAP (Rho G TPase a ctivating p rotein) domain usually function to
catalyze the hydrolysis of GTP that is bound to Rho, Rac and/or Cdc42, inactivating these …

The conversion of guanosine triphosphate (GTP) to guanosine diphosphate (GDP) and
inorganic phosphate (P i) by guanine nucleotide binding proteins (GNBPs) is a fundamental …

PIK3CA mutations are amongst the most prevalent somatic mutations in cancer and are
associated with resistance to first-line treatment along with low survival rates in a variety of …

Inactivation of host Rho GTPases is a widespread strategy employed by bacterial pathogens
to manipulate mammalian cellular functions and avoid immune defenses. Some bacterial …

The BAR (Bin/amphiphysin/Rvs) domain defines an emerging superfamily of proteins
implicated in fundamental biological processes by sensing and inducing membrane …

The role of endocytosis in controlling a multitude of cell biological events is well established.
Molecular and mechanistic characterization of endocytosis has predominantly focused on …

Changes in cell morphology require coordination of plasma membrane turnover and
cytoskeleton dynamics, processes that are regulated by Rho GTPases. Here, we describe …