Anti-inflammatory effect of muscle-derived interleukin-6 and its involvement in lipid metabolism

H Nara, R Watanabe - International journal of molecular sciences, 2021 - mdpi.com
Interleukin (IL)-6 has been studied since its discovery for its role in health and diseases. It is
one of the most important pro-inflammatory cytokines. IL-6 was reported as an exacerbating …

Functional role of skeletal muscle-derived interleukin-6 and its effects on lipid metabolism

W Lin, H Song, J Shen, J Wang, Y Yang… - Frontiers in …, 2023 - frontiersin.org
The detrimental impact of obesity on human health is increasingly evident with the rise in
obesity-related diseases. Skeletal muscle, the crucial organ responsible for energy balance …

Regulation of adipose tissue inflammation by interleukin 6

MS Han, A White, RJ Perry… - Proceedings of the …, 2020 - National Acad Sciences
Obesity is associated with a chronic state of low-grade inflammation and progressive tissue
infiltration by immune cells and increased expression of inflammatory cytokines. It is …

The role of exercise-induced myokines in promoting angiogenesis

C Qi, X Song, H Wang, Y Yan, B Liu - Frontiers in Physiology, 2022 - frontiersin.org
Ischemic diseases are a major cause of mortality or disability in the clinic. Surgical or
medical treatment often has poor effect on patients with tissue and organ ischemia caused …

[HTML][HTML] Chronic aerobic exercise improves insulin sensitivity and modulates Nrf2 and NF‑κB/IκBα pathways in the skeletal muscle of rats fed with a high fat diet

Q Yu, Z Xia, EC Liong, GL Tipoe - Molecular medicine …, 2019 - spandidos-publications.com
The present study aimed to investigate the molecular mechanisms of the ameliorative effects
of chronic aerobic exercise on non‑alcoholic steatohepatitis (NASH) in rat skeletal muscle …

Interleukin‐4 boosts insulin‐induced energy deposits by enhancing glucose uptake and lipogenesis in hepatocytes

CP Yang, MY Shiau, YR Lai, KT Ho… - Oxidative Medicine …, 2018 - Wiley Online Library
Type 2 diabetes mellitus (T2DM), with dysregulated hepatic gluconeogenesis as the major
cause of fasting hyperglycemia, is closely associated with chronic inflammation. We …

Unsaturated fatty acids from flaxseed oil and exercise modulate GPR120 but not GPR40 in the liver of obese mice: a new anti-inflammatory approach

RC Gaspar, CB Veiga, MP Bessi, MN Dátilo… - The Journal of nutritional …, 2019 - Elsevier
GPR120 and GPR40 were recently reported as omega-3 (ω3) receptors with anti-
inflammatory properties. Physical exercise could increase the expression of these receptors …

Skeletal muscle interleukin-6 regulates hepatic cytochrome P450 expression: effects of 16-week high-fat diet and exercise

JG Knudsen, L Bertholdt, A Gudiksen… - Toxicological …, 2018 - academic.oup.com
High-fat diet (HFD) induces several changes to the pathways regulating energy homeostasis
and changes the expression of the hepatic cytochrome p450 (Cyp) enzyme-system. Despite …

Exercise Affects the Formation and Recovery of Alcoholic Liver Disease through the IL-6–p47phox Oxidative–Stress Axis

W Cui, X Li, W Xue, H Wei, G Zhou, Y Qiu, D Cui - Cells, 2022 - mdpi.com
(1) Background: To explore the effect of exercise on the formation and recovery of alcoholic
liver disease (ALD) and whether the IL-6–p47phox oxidative–stress axis is involved in that …

[HTML][HTML] Role of interleukin-6 in inhibiting hepatic autophagy markers in exercised mice

AP Pinto, AL da Rocha, EMB Cabrera, BB Marafon… - Cytokine, 2020 - Elsevier
Background Based on the crosstalk of inflammation with apoptosis, autophagy, and
endoplasmic reticulum (ER) stress, the main objective of this study was to explore the role of …