Cancer, which is the uncontrolled growth of cells, is the second leading cause of death after
heart disease. Targeting drugs, especially to specific genes and proteins involved in growth …

Although the coordination chemistry of N-heterocyclic carbenes (NHCs) with transition
metals has been explored for half a century, only in the past ten years has the chemistry of …

The clinical success of platinum-based chemotherapeutic agents was of enormous impact
on the discovery of novel metal N-heterocyclic carbene (NHC) complexes as potential anti …

Silver coordination compounds with a number of different ligands (N-heterocyclic carbenes,
phosphines, N-heterocycles and others) possess several properties, ranging from …

A new era of metal-based drugs started in the 1960s, heralded by the discovery of potent
platinum-based complexes, commencing with cisplatin [(H3N) 2PtCl2], which are effective …

Over the course of the past 15 years the success story of N-heterocyclic carbene (NHC)
compounds in organic, inorganic, and organometallic chemistry has been extended to …

The electron-rich five-membered aromatic aza-heterocyclic imidazole, which contains two
nitrogen atoms, is an important functional fragment widely present in a large number of …

Within the research field of antitumor metal-based agents alternative to platinum drugs, gold
(I/III) coordination complexes have always been in the forefront due mainly to the familiarity …

Because of their great structural diversity and multitude of chemical properties, N-
heterocyclic carbenes (NHCs) have been utilized in a variety of capacities. Most recently …

Late transition metal complexes that bear N-heterocyclic carbene (NHC) ligands have seen
a speedy growth in their use as both, metal-based drug candidates and potentially active …