Clinical studies suggest that women are more likely than men to relapse to alcohol drinking
in response to stress; however, the mechanisms underlying this sex difference are not well …

Drug addiction is a chronic neuropsychiatric disorder that escalates from an initial exposure
to drugs of abuse, such as cocaine, cannabis, or heroin, to compulsive drug-seeking and …

Environmental enrichment is typically associated with enhanced well-being, improved
cognitive function and stress resilience. However, in some instances grouping adult male …

Environmental conditions, such as stress and environmental enrichment (EE), influence
predisposition to alcohol use/abuse; however, the underlying mechanisms remain unknown …

The hypothalamus-pituitary-adrenal axis (HPA) is the main regulator of the stress response.
The key of the HPA is the parvocellular paraventricular nucleus of the hypothalamus (pPVN) …

Previous research from our laboratory has shown that exposure to chronic psychosocial
stress increased voluntary ethanol consumption and preference as well as acquisition of …

Research has demonstrated that stress can exacerbate AD pathology in transgenic mouse
models of AD. The purpose of the present studies was to extend this work by determining …

Large preclinical evidence shows that exposure to social defeat (SD) increases vulnerability
to drug abuse, increasing the consumption of ethanol. However, not all subjects are equally …

Environmental enrichment (EE) provides a non-pharmacological tool to alter drug-induced
reward, yet its effects on ethanol-induced reward remain controversial. We analyzed …

Brain-derived neurotrophic factor (BDNF) is a crucial brain signaling protein that is integral
to many signaling pathways. This neurotrophin has shown to be highly involved in brain …